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Ttc21a tetratricopeptide repeat domain 21A [ Rattus norvegicus (Norway rat) ]

Gene ID: 301065, updated on 2-Nov-2024

Summary

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Official Symbol
Ttc21aprovided by RGD
Official Full Name
tetratricopeptide repeat domain 21Aprovided by RGD
Primary source
RGD:1308806
See related
EnsemblRapid:ENSRNOG00000034089 AllianceGenome:RGD:1308806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308806; Ttc21a-ps1
Summary
Predicted to be involved in several processes, including flagellated sperm motility; intraciliary retrograde transport; and protein localization to cilium. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle A. Human ortholog(s) of this gene implicated in spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 72.8), Lung (RPKM 22.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc21a in Genome Data Viewer
Location:
8q32
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128544684..128580464)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119667044..119702028)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128622414..128657199)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene prohibitin 1, pseudogene 2 Neighboring gene atherin-like Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene cysteine and serine rich nuclear protein 1 Neighboring gene uncharacterized LOC108351801

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice. Liu W, et al. Am J Hum Genet, 2019 Apr 4. PMID 30929735, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat domain 21A; tetratricopeptide repeat protein 21A
Names
tetratricopeptide repeat domain 21A, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429437.1 → NP_001416366.1  tetratricopeptide repeat domain 21A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZZJ4

  2. NM_001429438.1 → NP_001416367.1  tetratricopeptide repeat domain 21A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128544684..128580464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003750604.6 → XP_003750652.1  tetratricopeptide repeat protein 21A isoform X1

    Related
    ENSRNOP00000088686.2, ENSRNOT00000113289.2
    Conserved Domains (3) summary
    TIGR02917
    Location:215 → 1048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:883 → 911
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1198 → 1259
    TPR_11; TPR repeat

  2. XM_006244150.5 → XP_006244212.1  tetratricopeptide repeat protein 21A isoform X3

    See identical proteins and their annotated locations for XP_006244212.1

    Conserved Domains (2) summary
    TIGR02917
    Location:215 → 1048
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:883 → 911
    TPR; TPR repeat [structural motif]

  3. XM_039082725.2 → XP_038938653.1  tetratricopeptide repeat protein 21A isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5K9
    Conserved Domains (2) summary
    TIGR02917
    Location:105 → 938
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:773 → 801
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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