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Lrrfip2 LRR binding FLII interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301035, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrfip2provided by RGD
Official Full Name
LRR binding FLII interacting protein 2provided by RGD
Primary source
RGD:1306234
See related
EnsemblRapid:ENSRNOG00000021047 AllianceGenome:RGD:1306234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable LRR domain binding activity. Predicted to be involved in Wnt signaling pathway and regulation of DNA-templated transcription. Predicted to act upstream of or within regulation of gene expression and toll-like receptor signaling pathway. Orthologous to human LRRFIP2 (LRR binding FLII interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 310.8), Testes (RPKM 188.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrfip2 in Genome Data Viewer
Location:
8q32
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119969908..120071270)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (111091453..111193947)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119381666..119484125)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094383 Neighboring gene uncharacterized LOC102552504 Neighboring gene mutL homolog 1 Neighboring gene EPM2A interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. Fong KS, et al. Genomics, 1999 Jun 1. PMID 10366446
  2. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. Dai P, et al. J Immunol, 2009 Mar 15. PMID 19265123
  3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  5. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MyD88-dependent toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within MyD88-independent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat flightless-interacting protein 2
Names
LRR FLII-interacting protein 2
leucine rich repeat (in FLII) interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024761.1 → NP_001019932.1  leucine-rich repeat flightless-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001019932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC097955
    UniProtKB/Swiss-Prot
    Q4V7E8
    UniProtKB/TrEMBL
    A0A8I5ZMY2
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 362
    LRRFIP; LRRFIP family
    pfam11932
    Location:378 → 437
    DUF3450; Protein of unknown function (DUF3450)

  2. NM_001395739.1 → NP_001382668.1  leucine-rich repeat flightless-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZMY2
    Related
    ENSRNOP00000079448.2, ENSRNOT00000100197.2
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 349
    LRRFIP; LRRFIP family
    pfam11932
    Location:365 → 424
    DUF3450; Protein of unknown function (DUF3450)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119969908..120071270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766619.3 → XP_008764841.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008764841.1

    UniProtKB/TrEMBL
    A0A8I5ZUL9, A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 673
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:463 → 585
    MreC; rod shape-determining protein MreC

  2. XM_063265276.1 → XP_063121346.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

  3. XM_063265279.1 → XP_063121349.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

  4. XM_063265288.1 → XP_063121358.1  leucine-rich repeat flightless-interacting protein 2 isoform X32

  5. XM_063265281.1 → XP_063121351.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

  6. XM_063265287.1 → XP_063121357.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

  7. XM_063265285.1 → XP_063121355.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

  8. XM_063265292.1 → XP_063121362.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

    UniProtKB/TrEMBL
    A0A8I5ZQP7

  9. XM_063265291.1 → XP_063121361.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

  10. XM_008766616.4 → XP_008764838.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008764838.1

    UniProtKB/TrEMBL
    A0A8I5ZUL9, A0A8I6GLX7
    Related
    ENSRNOP00000082163.1, ENSRNOT00000108084.2
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 673
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:463 → 585
    MreC; rod shape-determining protein MreC

  11. XM_008766625.4 → XP_008764847.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GLX7
    Conserved Domains (3) summary
    pfam09738
    Location:319 → 639
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cd16269
    Location:493 → 504
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:369 → 504
    GBP_C; Guanylate-binding protein, C-terminal domain

  12. XM_017595600.3 → XP_017451089.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GLX7

  13. XM_006243939.4 → XP_006244001.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6AUZ7, A0A8I6GLX7
    Related
    ENSRNOP00000097455.1, ENSRNOT00000112179.2
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 608
    DUF2051; Double stranded RNA binding protein (DUF2051)
    pfam17031
    Location:375 → 431
    DUF5101; Domain of unknown function (DUF5101)

  14. XM_008766623.3 → XP_008764845.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 649
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:439 → 561
    MreC; rod shape-determining protein MreC

  15. XM_039081260.2 → XP_038937188.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 615
    LRRFIP; LRRFIP family
    pfam11932
    Location:631 → 690
    DUF3450; Protein of unknown function (DUF3450)

  16. XM_039081259.2 → XP_038937187.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 618
    LRRFIP; LRRFIP family
    pfam11932
    Location:634 → 693
    DUF3450; Protein of unknown function (DUF3450)

  17. XM_063265272.1 → XP_063121342.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

  18. XM_008766624.4 → XP_008764846.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:289 → 643
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:433 → 555
    MreC; rod shape-determining protein MreC

  19. XM_039081261.2 → XP_038937189.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:289 → 612
    LRRFIP; LRRFIP family
    pfam11932
    Location:628 → 687
    DUF3450; Protein of unknown function (DUF3450)

  20. XM_039081271.2 → XP_038937199.1  leucine-rich repeat flightless-interacting protein 2 isoform X13

    Conserved Domains (2) summary
    pfam09738
    Location:138 → 492
    LRRFIP; LRRFIP family
    pfam11932
    Location:508 → 567
    DUF3450; Protein of unknown function (DUF3450)

  21. XM_063265277.1 → XP_063121347.1  leucine-rich repeat flightless-interacting protein 2 isoform X20

  22. XM_063265273.1 → XP_063121343.1  leucine-rich repeat flightless-interacting protein 2 isoform X15

  23. XM_063265280.1 → XP_063121350.1  leucine-rich repeat flightless-interacting protein 2 isoform X23

  24. XM_039081272.2 → XP_038937200.1  leucine-rich repeat flightless-interacting protein 2 isoform X14

    UniProtKB/TrEMBL
    A6I3J0
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 469
    LRRFIP; LRRFIP family
    pfam11932
    Location:485 → 544
    DUF3450; Protein of unknown function (DUF3450)

  25. XM_063265275.1 → XP_063121345.1  leucine-rich repeat flightless-interacting protein 2 isoform X18

  26. XM_063265274.1 → XP_063121344.1  leucine-rich repeat flightless-interacting protein 2 isoform X17

  27. XM_063265278.1 → XP_063121348.1  leucine-rich repeat flightless-interacting protein 2 isoform X22

  28. XM_008766626.3 → XP_008764848.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A2V6
    Related
    ENSRNOP00000079352.2, ENSRNOT00000119180.2
    Conserved Domains (2) summary
    pfam09738
    Location:279 → 633
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:423 → 545
    MreC; rod shape-determining protein MreC

  29. XM_039081273.2 → XP_038937201.1  leucine-rich repeat flightless-interacting protein 2 isoform X16

    UniProtKB/TrEMBL
    A6I3J0
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 452
    LRRFIP; LRRFIP family
    pfam11932
    Location:468 → 527
    DUF3450; Protein of unknown function (DUF3450)

  30. XM_063265282.1 → XP_063121352.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A8I6AJ95

  31. XM_063265284.1 → XP_063121354.1  leucine-rich repeat flightless-interacting protein 2 isoform X29

  32. XM_039081277.2 → XP_038937205.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

    UniProtKB/TrEMBL
    A6I3J0
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 429
    LRRFIP; LRRFIP family
    pfam11932
    Location:445 → 504
    DUF3450; Protein of unknown function (DUF3450)

  33. XM_008766628.4 → XP_008764850.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A2V6
    Related
    ENSRNOP00000091298.2, ENSRNOT00000099949.2
    Conserved Domains (2) summary
    pfam09738
    Location:264 → 618
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:408 → 530
    MreC; rod shape-determining protein MreC

  34. XM_039081281.2 → XP_038937209.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

    UniProtKB/TrEMBL
    A6I3J0
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 414
    LRRFIP; LRRFIP family
    pfam11932
    Location:430 → 489
    DUF3450; Protein of unknown function (DUF3450)

  35. XM_063265283.1 → XP_063121353.1  leucine-rich repeat flightless-interacting protein 2 isoform X27

  36. XM_039081283.2 → XP_038937211.1  leucine-rich repeat flightless-interacting protein 2 isoform X26

    UniProtKB/TrEMBL
    A0A8I6A6N0, A6I3J0

  37. XM_039081282.2 → XP_038937210.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

    UniProtKB/TrEMBL
    A6I3J0
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 390
    LRRFIP; LRRFIP family
    pfam11932
    Location:406 → 465
    DUF3450; Protein of unknown function (DUF3450)

  38. XM_063265286.1 → XP_063121356.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

  39. XM_039081285.2 → XP_038937213.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

  40. XM_006243960.3 → XP_006244022.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

    UniProtKB/TrEMBL
    A0A8I5ZMY2, A0A8I5ZQP7
    Conserved Domains (2) summary
    pfam09738
    Location:47 → 325
    LRRFIP; LRRFIP family
    pfam11932
    Location:341 → 400
    DUF3450; Protein of unknown function (DUF3450)

  41. XM_039081286.2 → XP_038937214.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

    Conserved Domains (2) summary
    pfam09738
    Location:52 → 336
    LRRFIP; LRRFIP family
    pfam11932
    Location:352 → 411
    DUF3450; Protein of unknown function (DUF3450)

  42. XM_063265296.1 → XP_063121366.1  leucine-rich repeat flightless-interacting protein 2 isoform X39

  43. XM_063265295.1 → XP_063121365.1  leucine-rich repeat flightless-interacting protein 2 isoform X38

  44. XM_008766618.4 → XP_008764840.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008764840.1

    UniProtKB/TrEMBL
    A0A8I5ZUL9, A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 673
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:463 → 585
    MreC; rod shape-determining protein MreC

  45. XM_008766617.4 → XP_008764839.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008764839.1

    UniProtKB/TrEMBL
    A0A8I5ZUL9, A0A8I6GLX7
    Conserved Domains (2) summary
    pfam09738
    Location:319 → 673
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl19252
    Location:463 → 585
    MreC; rod shape-determining protein MreC

  46. XM_039081284.2 → XP_038937212.1  leucine-rich repeat flightless-interacting protein 2 isoform X28

    Conserved Domains (2) summary
    pfam09738
    Location:10 → 364
    LRRFIP; LRRFIP family
    pfam11932
    Location:380 → 439
    DUF3450; Protein of unknown function (DUF3450)

  47. XM_063265290.1 → XP_063121360.1  leucine-rich repeat flightless-interacting protein 2 isoform X33

  48. XM_063265293.1 → XP_063121363.1  leucine-rich repeat flightless-interacting protein 2 isoform X36

  49. XM_063265294.1 → XP_063121364.1  leucine-rich repeat flightless-interacting protein 2 isoform X37

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7E8.1 GenPept UniProtKB/Swiss-Prot:Q4V7E8

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