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Fbxo9 f-box protein 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300849, updated on 28-Oct-2024

Summary

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Official Symbol
Fbxo9provided by RGD
Official Full Name
f-box protein 9provided by RGD
Primary source
RGD:1310374
See related
EnsemblRapid:ENSRNOG00000008214 AllianceGenome:RGD:1310374
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of TOR signaling. Predicted to act upstream of or within fat cell differentiation and innate immune response. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO9 (F-box protein 9). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 239.5), Liver (RPKM 189.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo9 in Genome Data Viewer
Location:
8q31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87838787..87864362, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (78958482..78984015, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85388331..85413896, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene glial cells missing transcription factor 1 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 10 Neighboring gene ciliogenesis associated kinase 1 Neighboring gene ribosomal protein L12, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. F-box only protein 9 is required for adipocyte differentiation. Lee KW, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23643813
  2. Identification of novel genes that mediate innate immunity using inbred mice. Yang IV, et al. Genetics, 2009 Dec. PMID 19805818, Free PMC Article
  3. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Fernández-Sáiz V, et al. Nat Cell Biol, 2013 Jan. PMID 23263282
  4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
F-box only protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011998.1 → NP_001011998.1  F-box only protein 9

    See identical proteins and their annotated locations for NP_001011998.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085831
    UniProtKB/Swiss-Prot
    Q5U2X1
    UniProtKB/TrEMBL
    A0A8I5ZW08
    Conserved Domains (2) summary
    pfam12937
    Location:176 → 227
    F-box-like; F-box-like
    cl00299
    Location:80 → 111
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    87838787..87864362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081149.2 → XP_038937077.1  F-box only protein 9 isoform X2

    Related
    ENSRNOP00000100514.1, ENSRNOT00000150534.1
    Conserved Domains (1) summary
    pfam12937
    Location:212 → 258
    F-box-like

  2. XM_039081148.2 → XP_038937076.1  F-box only protein 9 isoform X1

    Related
    ENSRNOP00000010961.7, ENSRNOT00000010961.7
    Conserved Domains (1) summary
    pfam12937
    Location:211 → 257
    F-box-like

  3. XM_039081151.2 → XP_038937079.1  F-box only protein 9 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZW08, A0A8L2UIB1
    Related
    ENSRNOP00000083528.2, ENSRNOT00000104314.2
    Conserved Domains (1) summary
    pfam12937
    Location:178 → 224
    F-box-like

  4. XM_039081152.2 → XP_038937080.1  F-box only protein 9 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZW08, A0A8L2UIB1
    Conserved Domains (1) summary
    pfam12937
    Location:178 → 224
    F-box-like

  5. XM_039081153.2 → XP_038937081.1  F-box only protein 9 isoform X4

    UniProtKB/TrEMBL
    A6I1H2
    Conserved Domains (1) summary
    pfam12937
    Location:33 → 79
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2X1.1 GenPept UniProtKB/Swiss-Prot:Q5U2X1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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