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Dapk2 death-associated protein kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300799, updated on 17-Aug-2024

Summary

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Official Symbol
Dapk2provided by RGD
Official Full Name
death-associated protein kinase 2provided by RGD
Primary source
RGD:1304708
See related
EnsemblRapid:ENSRNOG00000017332 AllianceGenome:RGD:1304708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including anoikis; positive regulation of granulocyte chemotaxis; and regulation of apoptotic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Orthologous to human DAPK2 (death associated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 88.9), Muscle (RPKM 63.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dapk2 in Genome Data Viewer
Location:
8q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75601621..75720619)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66706536..66825567)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71822107..71941941)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 1 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene uncharacterized LOC108351731 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene uncharacterized LOC134480197

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2. Li S, et al. J Hum Genet, 2015 Nov. PMID 26334104
  2. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. Li H, et al. J Biol Chem, 2009 Jan 23. PMID 18957423
  3. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. Shani G, et al. EMBO J, 2001 Mar 1. PMID 11230133, Free PMC Article
  4. DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. Geering B, et al. J Leukoc Biol, 2014 Feb. PMID 24163421
  5. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Kawai T, et al. Oncogene, 1999 Jun 10. PMID 10376525

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
    Title: CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
  2. MiR-133a overexpression may inhibit I/R injury-mediated cardiomyocyte apoptosis by targeting DAPK2, leading to reduced DAPK2 protein.
    Title: Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109553

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anoikis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
death-associated protein kinase 2
Names
death-associated kinase 2
NP_001013127.1
NP_001382664.1
XP_008764463.1
XP_038937050.1
XP_038937053.1
XP_038937054.1
XP_063121234.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013109.1 → NP_001013127.1  death-associated protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001013127.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091410
    UniProtKB/TrEMBL
    F1LS59, Q5BJN2
    Conserved Domains (2) summary
    smart00220
    Location:2 → 130
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001395735.1 → NP_001382664.1  death-associated protein kinase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2JX07, A6J5H8
    Related
    ENSRNOP00000070087.2, ENSRNOT00000089147.3
    Conserved Domains (1) summary
    cd14196
    Location:12 → 280
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    75601621..75720619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081122.2 → XP_038937050.1  death-associated protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GD46
    Conserved Domains (2) summary
    TIGR02168
    Location:272 → 369
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl21453
    Location:12 → 203
    PKc_like; Protein Kinases, catalytic domain

  2. XM_008766241.4 → XP_008764463.1  death-associated protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GD46
    Related
    ENSRNOP00000085631.1, ENSRNOT00000098258.2
    Conserved Domains (2) summary
    smart00220
    Location:18 → 280
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:12 → 280
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  3. XM_063265164.1 → XP_063121234.1  death-associated protein kinase 2 isoform X4

  4. XM_039081125.2 → XP_038937053.1  death-associated protein kinase 2 isoform X3

    Conserved Domains (2) summary
    TIGR02168
    Location:199 → 291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039081126.2 → XP_038937054.1  death-associated protein kinase 2 isoform X3

    Conserved Domains (2) summary
    TIGR02168
    Location:199 → 291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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