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Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X [ Rattus norvegicus (Norway rat) ]

Gene ID: 300786, updated on 17-Aug-2024

Summary

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Official Symbol
Clpxprovided by RGD
Official Full Name
caseinolytic mitochondrial matrix peptidase chaperone subunit Xprovided by RGD
Primary source
RGD:1304883
See related
EnsemblRapid:ENSRNOG00000030225 AllianceGenome:RGD:1304883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and peptidase activator activity. Predicted to contribute to ATP-dependent peptidase activity. Predicted to be involved in ATP metabolic process and proteolysis involved in cellular protein catabolic process. Predicted to be located in cytosol; mitochondrial nucleoid; and nucleoplasm. Predicted to be part of mitochondrial endopeptidase Clp complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1351.0), Heart (RPKM 603.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clpx in Genome Data Viewer
Location:
8q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74700602..74740244)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65805460..65845643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70789137..70843133)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480196 Neighboring gene poly (ADP-ribose) polymerase family, member 16 Neighboring gene cartilage intermediate layer protein Neighboring gene programmed cell death 7 Neighboring gene ubiquitin associated protein 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. Lowth BR, et al. J Struct Biol, 2012 Aug. PMID 22710082
  2. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. Kang SG, et al. J Biol Chem, 2005 Oct 21. PMID 16115876
  3. Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP. Kang SG, et al. J Biol Chem, 2002 Jun 7. PMID 11923310
  4. Human and mouse mitochondrial orthologs of bacterial ClpX. Corydon TJ, et al. Mamm Genome, 2000 Oct. PMID 11003706
  5. Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP. de Sagarra MR, et al. J Mol Biol, 1999 Oct 1. PMID 10525407

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94617

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ATP-dependent peptidase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ATP-dependent peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis involved in protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of endopeptidase Clp complex ISO
Inferred from Sequence Orthology
more info
  
part_of endopeptidase Clp complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial endopeptidase Clp complex IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial endopeptidase Clp complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Names
ClpX caseinolytic peptidase X homolog
ClpX caseinolytic protease X homolog
caseinolytic peptidase X
caseinolytic protease X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007803.2 → NP_001007804.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001007804.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5U2U0
    UniProtKB/TrEMBL
    A0A8I6A7H5, A6J5E7
    Related
    ENSRNOP00000088647.2, ENSRNOT00000097161.2
    Conserved Domains (4) summary
    smart01086
    Location:509 → 603
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    TIGR00382
    Location:102 → 600
    clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
    pfam07724
    Location:286 → 502
    AAA_2; AAA domain (Cdc48 subfamily)
    cl02609
    Location:104 → 132
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    74700602..74740244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243250.3 → XP_006243312.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7H5
    Related
    ENSRNOP00000088175.1, ENSRNOT00000103006.2
    Conserved Domains (4) summary
    smart01086
    Location:495 → 589
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    TIGR00382
    Location:102 → 586
    clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
    pfam07724
    Location:272 → 488
    AAA_2; AAA domain (Cdc48 subfamily)
    cl02609
    Location:104 → 132
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

RNA

  1. XR_005487776.2 RNA Sequence

  2. XR_010053949.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2U0.1 GenPept UniProtKB/Swiss-Prot:Q5U2U0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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