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Mpi mannose phosphate isomerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 300741, updated on 28-Oct-2024

Summary

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Official Symbol
Mpiprovided by RGD
Official Full Name
mannose phosphate isomeraseprovided by RGD
Primary source
RGD:3107
See related
EnsemblRapid:ENSRNOG00000018898 AllianceGenome:RGD:3107
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process from fructose-6-phosphate; GDP-mannose biosynthetic process from glucose; and mannose to fructose-6-phosphate catabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Testes (RPKM 212.9), Muscle (RPKM 193.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mpi in Genome Data Viewer
Location:
8q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66843802..66852108, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57947883..57956205, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62324176..62332080, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene family with sequence similarity 219, member B Neighboring gene transfer RNA alanine (anticodon AGC) 55 Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51 like kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Metabolically programmed quality control system for dolichol-linked oligosaccharides. Harada Y, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218558, Free PMC Article
  2. Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. DeRossi C, et al. J Biol Chem, 2006 Mar 3. PMID 16339137
  3. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. Niehues R, et al. J Clin Invest, 1998 Apr 1. PMID 9525984, Free PMC Article
  4. Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Nichols EA, et al. Biochem Genet, 1973 Jan. PMID 4693062
  5. Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus). Otto J, et al. Biochem Genet, 1983 Feb. PMID 6838491

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC94106

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mannose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose-6-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannose-6-phosphate isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables mannose-6-phosphate isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose biosynthetic process from fructose-6-phosphate IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose biosynthetic process from fructose-6-phosphate ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP-mannose biosynthetic process from glucose IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose biosynthetic process from glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose to fructose-6-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mannose to fructose-6-phosphate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mannose to fructose-6-phosphate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mannose to fructose-6-phosphate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mannose-6-phosphate isomerase
Names
PMI
phosphohexomutase
phosphomannose isomerase
NP_001004081.1
XP_038937013.1
XP_038937015.1
XP_063121189.1
XP_063121190.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004081.1 → NP_001004081.1  mannose-6-phosphate isomerase

    See identical proteins and their annotated locations for NP_001004081.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079111
    UniProtKB/Swiss-Prot
    Q68FX1
    UniProtKB/TrEMBL
    A0A8I6ARZ5, A6J4W0
    Related
    ENSRNOP00000025783.4, ENSRNOT00000025783.7
    Conserved Domains (2) summary
    COG1482
    Location:9 → 402
    ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
    pfam01238
    Location:6 → 381
    PMI_typeI; Phosphomannose isomerase type I

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66843802..66852108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265119.1 → XP_063121189.1  mannose-6-phosphate isomerase isoform X3

  2. XM_039081087.2 → XP_038937015.1  mannose-6-phosphate isomerase isoform X2

    UniProtKB/TrEMBL
    A0A8I6AKP8
    Related
    ENSRNOP00000093777.2, ENSRNOT00000113263.2
    Conserved Domains (1) summary
    pfam01238
    Location:6 → 323
    PMI_typeI; Phosphomannose isomerase type I

  3. XM_039081085.2 → XP_038937013.1  mannose-6-phosphate isomerase isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARZ5
    Conserved Domains (1) summary
    pfam01238
    Location:1 → 331
    PMI_typeI; Phosphomannose isomerase type I

  4. XM_063265120.1 → XP_063121190.1  mannose-6-phosphate isomerase isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FX1.1 GenPept UniProtKB/Swiss-Prot:Q68FX1

Gene LinkOut

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