U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bcl9l BCL9 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 300673, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Bcl9lprovided by RGD
Official Full Name
BCL9 likeprovided by RGD
Primary source
RGD:1309096
See related
EnsemblRapid:ENSRNOG00000012420 AllianceGenome:RGD:1309096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of epithelial to mesenchymal transition. Predicted to act upstream of or within skeletal muscle cell differentiation and somatic stem cell population maintenance. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Orthologous to human BCL9L (BCL9 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 44.7), Adrenal (RPKM 44.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Bcl9l in Genome Data Viewer
Location:
8q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53708770..53738880)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44811977..44840611)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48805684..48835794)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene forkhead box R1 Neighboring gene uroplakin 2 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene uncharacterized LOC120094133 Neighboring gene DEAD-box helicase 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Deka J, et al. Cancer Res, 2010 Aug 15. PMID 20682801
  2. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Brack AS, et al. Dev Biol, 2009 Nov 1. PMID 19699733, Free PMC Article
  3. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Fritzmann J, et al. Gastroenterology, 2009 Jul. PMID 19328798
  4. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Adachi S, et al. Cancer Res, 2004 Dec 1. PMID 15574752
  5. Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. van Tienen LM, et al. Elife, 2017 Mar 15. PMID 28296634, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
B-cell CLL/lymphoma 9-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106817.1 → NP_001100287.1  B-cell CLL/lymphoma 9-like protein

    See identical proteins and their annotated locations for NP_001100287.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A0A8I6GJW6, A6J400, D4A0D9
    Related
    ENSRNOP00000061788.1, ENSRNOT00000064041.3
    Conserved Domains (1) summary
    pfam11502
    Location:395 → 434
    BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53708770..53738880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595551.3 → XP_017451040.1  B-cell CLL/lymphoma 9-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6Y0, A0A8I6AJN4
    Related
    ENSRNOP00000093456.1, ENSRNOT00000102843.2

  2. XM_039081056.2 → XP_038936984.1  B-cell CLL/lymphoma 9-like protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJW6
    Conserved Domains (2) summary
    PHA03247
    Location:851 → 1314
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:358 → 397
    BCL9; B-cell lymphoma 9 protein

  3. XM_017595552.3 → XP_017451041.1  B-cell CLL/lymphoma 9-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6Y0, A0A8I6AJN4

  4. XM_006242923.5 → XP_006242985.1  B-cell CLL/lymphoma 9-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6Y0
    Related
    ENSRNOP00000091789.2, ENSRNOT00000104981.2
    Conserved Domains (1) summary
    pfam11502
    Location:442 → 481
    BCL9; B-cell lymphoma 9 protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools