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Myg1 MYG1 exonuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 300258, updated on 28-Oct-2024

Summary

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Official Symbol
Myg1provided by RGD
Official Full Name
MYG1 exonucleaseprovided by RGD
Primary source
RGD:1359237
See related
EnsemblRapid:ENSRNOG00000013343 AllianceGenome:RGD:1359237
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C12orf10
Summary
Predicted to enable nuclease activity. Predicted to act upstream of or within locomotory exploration behavior. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MYG1 (MYG1 exonuclease). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 149.3), Kidney (RPKM 126.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myg1 in Genome Data Viewer
Location:
7q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135335364..135342567)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133456778..133463985)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143929662..143936865)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene extra spindle pole bodies like 1, separase Neighboring gene uncharacterized LOC134479583 Neighboring gene prefoldin subunit 5 Neighboring gene aladin WD repeat nucleoporin Neighboring gene Sp7 transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1. Philips MA, et al. BMC Med Genet, 2010 Apr 8. PMID 20377893, Free PMC Article
  2. Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences. Philips MA, et al. Behav Brain Res, 2010 Feb 11. PMID 19818808
  3. Characterization of MYG1 gene and protein: subcellular distribution and function. Philips MA, et al. Biol Cell, 2009 Jun. PMID 19014353
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95325

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MYG1 exonuclease
Names
UPF0160 protein MYG1, mitochondrial
melanocyte proliferating gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005545.1 → NP_001005545.1  MYG1 exonuclease precursor

    See identical proteins and their annotated locations for NP_001005545.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082112
    UniProtKB/Swiss-Prot
    Q641W2
    Related
    ENSRNOP00000017942.3, ENSRNOT00000017942.8
    Conserved Domains (1) summary
    pfam03690
    Location:46 → 366
    UPF0160; uncharacterized protein family (UPF0160)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135335364..135342567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078940.2 → XP_038934868.1  MYG1 exonuclease isoform X1

    Conserved Domains (1) summary
    pfam03690
    Location:2 → 257
    UPF0160; Uncharacterized protein family (UPF0160)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q641W2.1 GenPept UniProtKB/Swiss-Prot:Q641W2

Gene LinkOut

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