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Senp1 SUMO specific peptidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300193, updated on 2-Nov-2024

Summary

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Symbol
Senp1provided by RGD
Full Name
SUMO specific peptidase 1provided by RGD
Primary source
RGD:1310275
See related
EnsemblRapid:ENSRNOG00000022260 AllianceGenome:RGD:1310275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 77.7), Spleen (RPKM 67.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Senp1 in Genome Data Viewer
Location:
7q36
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131042237..131105826, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129163173..129226766, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (139626444..139684587, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106C Neighboring gene collagen type II alpha 1 chain Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phosphofructokinase, muscle Neighboring gene uncharacterized LOC134479569 Neighboring gene transfer RNA threonine (anticodon AGU) 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation. Bai YT, et al. Int J Med Sci, 2021. PMID 33746578, Free PMC Article
  2. Homeostatic synaptic scaling is regulated by protein SUMOylation. Craig TJ, et al. J Biol Chem, 2012 Jun 29. PMID 22582390, Free PMC Article
  3. [The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension]. Tian H, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2012 Mar. PMID 22737911
  4. SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Zhou F, et al. Mol Med Rep, 2016 Apr. PMID 26935971, Free PMC Article
  5. SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells. Wan XQ, et al. Int J Mol Med, 2019 Jan. PMID 30387808, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
    Title: Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
  2. Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation.
    Title: Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation.
  3. SENP1 is an essential regulator of the balance between SUMOylation and deSUMOylation during lung development, specifically affecting the proliferation and differentiation status of AT2 cells.
    Title: SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells.
  4. Lastly, the SENP1 knockdown HSC-T6 cells were successfully constructed, while the silence of SENP1 down-regulated the protein expression of alpha-SMA and SMAD2. In conclusion, this study provided a new regulation mechanism about the liver fibrosis process.
    Title: SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2.
  5. SUMOspecific protease 1 was able to enhance the proliferative ability of pulmonary artery smooth muscle cells by initiating deSUMOylation of hypoxiainducible factor1alpha and increasing the expression of its downstream responsive gene, Vascular Endothelial Growth Factor.
    Title: SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α.
  6. analysis of the SENP-1 mediated SUMOylation-dependent regulatory pathway for GlyR endocytosis, which may have important physiological implications for proper neuronal excitability
    Title: Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation.
  7. SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha-dependent pathway.
    Title: SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway.
  8. The dynamic expression of SENP1 protein may play a role in the development of hypoxic pulmonary hypertension.
    Title: [The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension].
  9. Protein SUMOylation via senp1 plays an important and previously unsuspected role in synaptic trafficking of AMPARs that underlies homeostatic scaling.
    Title: Homeostatic synaptic scaling is regulated by protein SUMOylation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deSUMOylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of definitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sentrin-specific protease 1
Names
SUMO1/sentrin specific peptidase 1
SUMO1/sentrin specific protease 1
Sumo1/sentrin/SMT3 specific peptidase 1
sentrin-specific protease 1-like
XP_008764066.1
XP_008764070.1
XP_008764071.1
XP_008764072.1
XP_017450803.1
XP_017450804.1
XP_017450805.1
XP_017450806.1
XP_038936284.1
XP_038936285.1
XP_038936286.1
XP_038936287.1
XP_038936288.1
XP_038936289.1
XP_063120428.1
XP_063120429.1
XP_063120430.1
XP_063120431.1
XP_063120432.1
XP_063120433.1
XP_063120434.1
XP_063120435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432472.1 → NP_001419401.1  sentrin-specific protease 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  2. NM_001432473.1 → NP_001419402.1  sentrin-specific protease 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  3. NM_001432474.1 → NP_001419403.1  sentrin-specific protease 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  4. NM_001432476.1 → NP_001419405.1  sentrin-specific protease 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131042237..131105826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080358.2 → XP_038936286.1  sentrin-specific protease 1 isoform X7

    UniProtKB/TrEMBL
    F1LVT6
    Conserved Domains (2) summary
    PRK04863
    Location:401 → 495
    mukB; chromosome partition protein MukB
    cl23802
    Location:468 → 690
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. XM_039080359.1 → XP_038936287.1  sentrin-specific protease 1 isoform X7

    UniProtKB/TrEMBL
    F1LVT6
    Conserved Domains (2) summary
    PRK04863
    Location:401 → 495
    mukB; chromosome partition protein MukB
    cl23802
    Location:468 → 690
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  3. XM_063264363.1 → XP_063120433.1  sentrin-specific protease 1 isoform X15

  4. XM_063264361.1 → XP_063120431.1  sentrin-specific protease 1 isoform X12

  5. XM_008765850.4 → XP_008764072.1  sentrin-specific protease 1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JVG1, F1LVT6
    Conserved Domains (1) summary
    cl23802
    Location:428 → 650
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  6. XM_008765848.3 → XP_008764070.1  sentrin-specific protease 1 isoform X9

    Related
    ENSRNOP00000107988.1, ENSRNOT00000150146.1
    Conserved Domains (1) summary
    cl23802
    Location:454 → 676
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  7. XM_063264359.1 → XP_063120429.1  sentrin-specific protease 1 isoform X8

  8. XM_017595317.3 → XP_017450806.1  sentrin-specific protease 1 isoform X7

    UniProtKB/TrEMBL
    F1LVT6
    Conserved Domains (2) summary
    PRK04863
    Location:401 → 495
    mukB; chromosome partition protein MukB
    cl23802
    Location:468 → 690
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  9. XM_063264362.1 → XP_063120432.1  sentrin-specific protease 1 isoform X13

  10. XM_063264360.1 → XP_063120430.1  sentrin-specific protease 1 isoform X10

  11. XM_063264358.1 → XP_063120428.1  sentrin-specific protease 1 isoform X5

  12. XM_017595314.3 → XP_017450803.1  sentrin-specific protease 1 isoform X2

    UniProtKB/TrEMBL
    F1LVT6

  13. XM_039080356.2 → XP_038936284.1  sentrin-specific protease 1 isoform X1

    UniProtKB/TrEMBL
    F1LVT6
    Conserved Domains (2) summary
    PRK04863
    Location:433 → 527
    mukB; chromosome partition protein MukB
    cl23802
    Location:500 → 722
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  14. XM_039080357.2 → XP_038936285.1  sentrin-specific protease 1 isoform X7

    UniProtKB/TrEMBL
    F1LVT6
    Conserved Domains (2) summary
    PRK04863
    Location:401 → 495
    mukB; chromosome partition protein MukB
    cl23802
    Location:468 → 690
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  15. XM_008765849.3 → XP_008764071.1  sentrin-specific protease 1 isoform X11

    Related
    ENSRNOP00000069472.3, ENSRNOT00000080056.3
    Conserved Domains (1) summary
    cl23802
    Location:448 → 670
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  16. XM_008765844.3 → XP_008764066.1  sentrin-specific protease 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K1R8, F1LVT6
    Related
    ENSRNOP00000071957.3, ENSRNOT00000089425.3
    Conserved Domains (1) summary
    cl23802
    Location:486 → 708
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  17. XM_017595315.3 → XP_017450804.1  sentrin-specific protease 1 isoform X3

    UniProtKB/TrEMBL
    F1LVT6

  18. XM_017595316.3 → XP_017450805.1  sentrin-specific protease 1 isoform X6

    UniProtKB/TrEMBL
    F1LVT6
    Related
    ENSRNOP00000031127.6, ENSRNOT00000030943.8

  19. XM_063264364.1 → XP_063120434.1  sentrin-specific protease 1 isoform X16

  20. XM_063264365.1 → XP_063120435.1  sentrin-specific protease 1 isoform X16

  21. XM_039080360.2 → XP_038936288.1  sentrin-specific protease 1 isoform X16

    Conserved Domains (2) summary
    COG5160
    Location:228 → 467
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    PRK04863
    Location:176 → 270
    mukB; chromosome partition protein MukB

  22. XM_039080361.2 → XP_038936289.1  sentrin-specific protease 1 isoform X17

RNA

  1. XR_005487405.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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