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SH3KBP1 SH3 domain containing kinase binding protein 1 [ Homo sapiens (human) ]

Gene ID: 30011, updated on 2-Nov-2024

Summary

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Official Symbol
SH3KBP1provided by HGNC
Official Full Name
SH3 domain containing kinase binding protein 1provided by HGNC
Primary source
HGNC:HGNC:13867
See related
Ensembl:ENSG00000147010 MIM:300374; AllianceGenome:HGNC:13867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSB1; AGMX2; CIN85; GIG10; HSB-1; IMD61; MIG18; CD2BP3
Summary
This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in lymph node (RPKM 19.2), fat (RPKM 15.0) and 24 other tissues See more
Orthologs
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Genomic context

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See SH3KBP1 in Genome Data Viewer
Location:
Xp22.12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (19533977..19887600, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (19116856..19470507, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (19552095..19905718, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:19391289-19392229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29463 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene pyruvate dehydrogenase E1 subunit alpha 1 Neighboring gene eukaryotic translation initiation factor 5 pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:19643274-19644473 Neighboring gene uncharacterized LOC124905255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:19740595-19741095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:19820680-19821600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29470 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:19880674-19881280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29476 Neighboring gene uncharacterized LOC124905256 Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:20001035-20001226 Neighboring gene uncharacterized LOC729609

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex. Havrylov S, et al. Traffic, 2008 May. PMID 18266907
  2. Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma MCF-7 cells. Vynnytska-Myronovska BO, et al. Ukr Biochem J, 2014 Sep-Oct. PMID 25816594
  3. Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85. Philippe D, et al. Biochemistry, 2011 May 10. PMID 21446695
  4. Adaptor protein Ruk1 forms protein-protein complexes with endonuclease activity in HEK293 cells. Kit YY, et al. Biochemistry (Mosc), 2003 Jul. PMID 12946264
  5. The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation. Kühn J, et al. Sci Signal, 2016 Jun 28. PMID 27353366

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
    Title: E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
  2. High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma.
    Title: High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma.
  3. In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain.
    Title: In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain.
  4. The three N-terminal SH3 domains of CIN85 bind to the N-terminus of PHD2.
    Title: The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
  5. These results reveal nonredundant functions of CIN85 for humoral immune responses.
    Title: Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.
  6. These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation.
    Title: Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.
  7. Transcriptional regulation of NOX genes expression in human breast adenocarcinoma cells is modulated by adaptor protein CIN85.
    Title: Transcriptional regulation of NOX genes express ion in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN 85.
  8. The multiple Src homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process.
    Title: The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.
  9. these data support a role for the novel PP2Ac-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
    Title: A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling.
  10. CIN85 promotes recycling of TGF-beta receptors and thereby positively regulates TGF-beta signaling.
    Title: CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 61
MedGen: C1845903 OMIM: 300310 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies SH3KBP1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 domain-containing kinase-binding protein 1
Names
CD2-binding protein 3
SH3-domain kinase binding protein 1
Src family kinase-binding protein 1
c-Cbl-interacting protein
cbl-interacting protein of 85 kDa
human Src family kinase-binding protein 1
migration-inducing gene 18
src-related kinase binding protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021367.1 RefSeqGene

    Range
    5027..358650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024666.3 → NP_001019837.1  SH3 domain-containing kinase-binding protein 1 isoform b

    See identical proteins and their annotated locations for NP_001019837.1

    Status: REVIEWED

    Source sequence(s)
    AF542051, AL732423, DC409010
    Consensus CDS
    CCDS35213.1
    UniProtKB/TrEMBL
    A0A8V8TQD8
    Related
    ENSP00000514545.1, ENST00000699723.1
    Conserved Domains (2) summary
    cd12055
    Location:65 → 117
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:234 → 289
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  2. NM_001184960.2 → NP_001171889.1  SH3 domain-containing kinase-binding protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AK293237, AL732327, AL732423, BP224209
    Consensus CDS
    CCDS55383.1
    UniProtKB/Swiss-Prot
    Q96B97
    Related
    ENSP00000369039.1, ENST00000379716.5
    Conserved Domains (1) summary
    cd12057
    Location:33 → 88
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  3. NM_001353890.2 → NP_001340819.1  SH3 domain-containing kinase-binding protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423, AL772197
    Consensus CDS
    CCDS94571.1
    UniProtKB/TrEMBL
    A0A8V8TP33, A0A8V8TQD8
    Related
    ENSP00000514516.1, ENST00000699673.1
    Conserved Domains (3) summary
    cd12052
    Location:3 → 55
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102 → 154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:271 → 326
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  4. NM_001353891.2 → NP_001340820.1  SH3 domain-containing kinase-binding protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423, AL772197
    Consensus CDS
    CCDS94573.1
    UniProtKB/TrEMBL
    A0A8V8TP27, A0A8V8TQD8
    Related
    ENSP00000514511.1, ENST00000699668.1
    Conserved Domains (3) summary
    cd12052
    Location:3 → 55
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102 → 154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:296 → 351
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  5. NM_001353892.2 → NP_001340821.1  SH3 domain-containing kinase-binding protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423, AL772197
    Consensus CDS
    CCDS94572.1
    UniProtKB/TrEMBL
    A0A8V8TNT5, A0A8V8TQD8
    Related
    ENSP00000514514.1, ENST00000699671.1
    Conserved Domains (3) summary
    cd12052
    Location:3 → 55
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102 → 154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:296 → 351
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  6. NM_001353893.2 → NP_001340822.1  SH3 domain-containing kinase-binding protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423
    Consensus CDS
    CCDS94568.1
    UniProtKB/TrEMBL
    A0A8V8TQG3, A0A8V8TQU1
    Related
    ENSP00000514711.1, ENST00000699726.1
    Conserved Domains (2) summary
    cd12055
    Location:43 → 95
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:237 → 292
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  7. NM_001353894.2 → NP_001340823.1  SH3 domain-containing kinase-binding protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423
    Consensus CDS
    CCDS94567.1
    UniProtKB/TrEMBL
    A0A8V8TP40, A0A8V8TQG3
    Related
    ENSP00000514713.1, ENST00000699733.1
    Conserved Domains (2) summary
    cd12055
    Location:43 → 95
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:237 → 292
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  8. NM_001353895.2 → NP_001340824.1  SH3 domain-containing kinase-binding protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423
    Consensus CDS
    CCDS94569.1
    UniProtKB/TrEMBL
    A0A8V8TPM1, A0A8V8TQG3
    Related
    ENSP00000514710.1, ENST00000699720.1
    Conserved Domains (2) summary
    cd12055
    Location:43 → 95
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:256 → 311
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  9. NM_001353897.2 → NP_001340826.1  SH3 domain-containing kinase-binding protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL732327, AL732423
    Consensus CDS
    CCDS94565.1
    UniProtKB/TrEMBL
    A0A8V8TP69
    Related
    ENSP00000514555.1, ENST00000699738.1
    Conserved Domains (2) summary
    cd12057
    Location:33 → 88
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    cl25508
    Location:325 → 384
    Spc7; Spc7 kinetochore protein

  10. NM_001410756.1 → NP_001397685.1  SH3 domain-containing kinase-binding protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423, AL772197
    Consensus CDS
    CCDS94575.1
    UniProtKB/TrEMBL
    Q5JPT2
    Related
    ENSP00000369049.4, ENST00000379726.8

  11. NM_001410757.1 → NP_001397686.1  SH3 domain-containing kinase-binding protein 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423, AL772197
    Consensus CDS
    CCDS94574.1
    UniProtKB/TrEMBL
    A0A8V8TNL0
    Related
    ENSP00000514513.1, ENST00000699670.1

  12. NM_001410758.1 → NP_001397687.1  SH3 domain-containing kinase-binding protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL732325, AL732327, AL732423
    Consensus CDS
    CCDS94566.1
    UniProtKB/TrEMBL
    A0A8V8TP63
    Related
    ENSP00000514549.1, ENST00000699729.1

  13. NM_031892.3 → NP_114098.1  SH3 domain-containing kinase-binding protein 1 isoform a

    See identical proteins and their annotated locations for NP_114098.1

    Status: REVIEWED

    Source sequence(s)
    AF230904, AL732423
    Consensus CDS
    CCDS14193.1
    UniProtKB/Swiss-Prot
    B7Z1D5, Q5JPT4, Q5JPT5, Q8IWX6, Q8IX98, Q96B97, Q96RN4, Q9NYR0
    UniProtKB/TrEMBL
    A0A8V8TQD8, Q5JPT6
    Related
    ENSP00000380921.3, ENST00000397821.8
    Conserved Domains (3) summary
    cd12052
    Location:3 → 55
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102 → 154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:271 → 326
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    19533977..19887600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029468.3 → XP_016884957.1  SH3 domain-containing kinase-binding protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8V8TQG3

  2. XM_047442043.1 → XP_047297999.1  SH3 domain-containing kinase-binding protein 1 isoform X7

  3. XM_017029467.3 → XP_016884956.1  SH3 domain-containing kinase-binding protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TQG3

  4. XM_017029461.2 → XP_016884950.1  SH3 domain-containing kinase-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V8TQD8

  5. XM_017029460.2 → XP_016884949.1  SH3 domain-containing kinase-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TQD8

  6. XM_047442044.1 → XP_047298000.1  SH3 domain-containing kinase-binding protein 1 isoform X8

    Related
    ENST00000699722.1

  7. XM_047442040.1 → XP_047297996.1  SH3 domain-containing kinase-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V8TNW8
    Related
    ENSP00000514547.1, ENST00000699725.1

  8. XM_047442047.1 → XP_047298003.1  SH3 domain-containing kinase-binding protein 1 isoform X11

  9. XM_011545499.4 → XP_011543801.1  SH3 domain-containing kinase-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TQD8
    Conserved Domains (2) summary
    cd12055
    Location:65 → 117
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:278 → 333
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  10. XM_047442048.1 → XP_047298004.1  SH3 domain-containing kinase-binding protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8V8TP63

  11. XM_047442045.1 → XP_047298001.1  SH3 domain-containing kinase-binding protein 1 isoform X8

  12. XM_047442041.1 → XP_047297997.1  SH3 domain-containing kinase-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V8TNW8

  13. XM_047442046.1 → XP_047298002.1  SH3 domain-containing kinase-binding protein 1 isoform X10

  14. XM_047442042.1 → XP_047297998.1  SH3 domain-containing kinase-binding protein 1 isoform X6

  15. XM_047442039.1 → XP_047297995.1  SH3 domain-containing kinase-binding protein 1 isoform X1

  16. XM_017029469.2 → XP_016884958.1  SH3 domain-containing kinase-binding protein 1 isoform X16

    UniProtKB/TrEMBL
    B7Z6E8
    Related
    ENST00000699736.1
    Conserved Domains (2) summary
    cd12057
    Location:10 → 65
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    pfam10267
    Location:339 → 396
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  17. XM_047442050.1 → XP_047298006.1  SH3 domain-containing kinase-binding protein 1 isoform X17

  18. XM_011545502.3 → XP_011543804.1  SH3 domain-containing kinase-binding protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8V8TQF6
    Related
    ENSP00000514544.1, ENST00000699721.1
    Conserved Domains (1) summary
    cd12057
    Location:50 → 105
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

  19. XM_011545503.4 → XP_011543805.1  SH3 domain-containing kinase-binding protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8V8TNS8
    Conserved Domains (3) summary
    cd12052
    Location:3 → 55
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102 → 154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315 → 370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    19116856..19470507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326929.1 → XP_054182904.1  SH3 domain-containing kinase-binding protein 1 isoform X9

  2. XM_054326923.1 → XP_054182898.1  SH3 domain-containing kinase-binding protein 1 isoform X3

  3. XM_054326933.1 → XP_054182908.1  SH3 domain-containing kinase-binding protein 1 isoform X12

  4. XM_054326927.1 → XP_054182902.1  SH3 domain-containing kinase-binding protein 1 isoform X7

  5. XM_054326925.1 → XP_054182900.1  SH3 domain-containing kinase-binding protein 1 isoform X5

  6. XM_054326928.1 → XP_054182903.1  SH3 domain-containing kinase-binding protein 1 isoform X8

  7. XM_054326924.1 → XP_054182899.1  SH3 domain-containing kinase-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V8TNW8

  8. XM_054326932.1 → XP_054182907.1  SH3 domain-containing kinase-binding protein 1 isoform X11

  9. XM_054326922.1 → XP_054182897.1  SH3 domain-containing kinase-binding protein 1 isoform X2

  10. XM_054326934.1 → XP_054182909.1  SH3 domain-containing kinase-binding protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8V8TP63

  11. XM_054326930.1 → XP_054182905.1  SH3 domain-containing kinase-binding protein 1 isoform X8

  12. XM_054326926.1 → XP_054182901.1  SH3 domain-containing kinase-binding protein 1 isoform X6

  13. XM_054326931.1 → XP_054182906.1  SH3 domain-containing kinase-binding protein 1 isoform X10

  14. XM_054326921.1 → XP_054182896.1  SH3 domain-containing kinase-binding protein 1 isoform X1

  15. XM_054326937.1 → XP_054182912.1  SH3 domain-containing kinase-binding protein 1 isoform X16

    UniProtKB/TrEMBL
    B7Z6E8

  16. XM_054326939.1 → XP_054182914.1  SH3 domain-containing kinase-binding protein 1 isoform X17

  17. XM_054326935.1 → XP_054182910.1  SH3 domain-containing kinase-binding protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8V8TQF6

  18. XM_054326938.1 → XP_054182913.1  SH3 domain-containing kinase-binding protein 1 isoform X16

    UniProtKB/TrEMBL
    B7Z6E8

  19. XM_054326936.1 → XP_054182911.1  SH3 domain-containing kinase-binding protein 1 isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96B97.2 GenPept UniProtKB/Swiss-Prot:Q96B97

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