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Pycr3 pyrroline-5-carboxylate reductase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300035, updated on 2-Nov-2024

Summary

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Official Symbol
Pycr3provided by RGD
Official Full Name
pyrroline-5-carboxylate reductase 3provided by RGD
Primary source
RGD:1309115
See related
AllianceGenome:RGD:1309115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pycrl
Summary
Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Predicted to be part of eukaryotic translation elongation factor 1 complex. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 121.2), Kidney (RPKM 103.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pycr3 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109484263..109489554, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107603543..107608831, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116949882..116955150, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5 Neighboring gene GDP-L-fucose synthase Neighboring gene zinc finger protein 623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. Merrill MJ, et al. J Biol Chem, 1989 Jun 5. PMID 2722838
  2. Functional specialization in proline biosynthesis of melanoma. De Ingeniis J, et al. PLoS One, 2012. PMID 23024808, Free PMC Article
  3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrroline-5-carboxylate reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrroline-5-carboxylate reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-proline biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-proline biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyrroline-5-carboxylate reductase 3
Names
P5C reductase 3
P5CR 3
pyrroline-5-carboxylate reductase-like protein
NP_001011993.1
XP_038934748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011993.1 → NP_001011993.1  pyrroline-5-carboxylate reductase 3

    See identical proteins and their annotated locations for NP_001011993.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087166
    UniProtKB/Swiss-Prot
    Q5PQJ6
    UniProtKB/TrEMBL
    A6HS37
    Conserved Domains (3) summary
    PLN02688
    Location:10 → 273
    PLN02688; pyrroline-5-carboxylate reductase
    pfam03807
    Location:12 → 104
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:166 → 270
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109484263..109489554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078820.2 → XP_038934748.1  pyrroline-5-carboxylate reductase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UQA6
    Conserved Domains (1) summary
    PLN02688
    Location:10 → 288
    PLN02688; pyrroline-5-carboxylate reductase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQJ6.1 GenPept UniProtKB/Swiss-Prot:Q5PQJ6

Gene LinkOut

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