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Ly6h lymphocyte antigen 6 family member H [ Rattus norvegicus (Norway rat) ]

Gene ID: 300025, updated on 17-Aug-2024

Summary

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Official Symbol
Ly6hprovided by RGD
Official Full Name
lymphocyte antigen 6 family member Hprovided by RGD
Primary source
RGD:1311896
See related
AllianceGenome:RGD:1311896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be located in synapse. Predicted to be active in plasma membrane. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 225.6) See more
Orthologs
human mouse all
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Genomic context

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See Ly6h in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109139527..109142108, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107258779..107261270, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116605556..116608072, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Ly6-C antigen like 1 Neighboring gene lymphocyte antigen 6 complex, locus A-like Neighboring gene lymphocyte antigen 6 family member L Neighboring gene glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 Neighboring gene zinc finger protein 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. Wu M, et al. J Biol Chem, 2015 Oct 2. PMID 26276394, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6H
Names
lymphocyte antigen 6 complex, locus H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134839.1 → NP_001128311.1  lymphocyte antigen 6H precursor

    See identical proteins and their annotated locations for NP_001128311.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HS09
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109139527..109142108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263270.1 → XP_063119340.1  lymphocyte antigen 6H isoform X1

    UniProtKB/TrEMBL
    A0A096MJ69, B5DFM3

  2. XM_006241783.5 → XP_006241845.1  lymphocyte antigen 6H isoform X2

    See identical proteins and their annotated locations for XP_006241845.1

    UniProtKB/TrEMBL
    A6HS09
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

  3. XM_039078805.2 → XP_038934733.1  lymphocyte antigen 6H isoform X2

    UniProtKB/TrEMBL
    A6HS09
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

  4. XM_039078804.2 → XP_038934732.1  lymphocyte antigen 6H isoform X2

    UniProtKB/TrEMBL
    A6HS09
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain
Nucleotide Protein Strain
Heading Accession and Version

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