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Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 299957, updated on 2-Nov-2024

Summary

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Official Symbol
Nsmce2provided by RGD
Official Full Name
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligaseprovided by RGD
Primary source
RGD:1305156
See related
EnsemblRapid:ENSRNOG00000003964 AllianceGenome:RGD:1305156
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305156
Summary
Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 44.1), Adrenal (RPKM 36.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsmce2 in Genome Data Viewer
Location:
7q33
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (92825568..93071037)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (90936112..91173435)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (99677295..99900765)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene squalene epoxidase Neighboring gene WASH complex subunit 5 Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene uncharacterized LOC134479917 Neighboring gene uncharacterized LOC108351497 Neighboring gene hypothetical protein LOC690120

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SMC5 and MMS21 are required for chromosome cohesion and mitotic progression. Behlke-Steinert S, et al. Cell Cycle, 2009 Jul 15. PMID 19502785
  2. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Potts PR, et al. Mol Cell Biol, 2005 Aug. PMID 16055714, Free PMC Article
  3. Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Wu N, et al. Genes Dev, 2012 Jul 1. PMID 22751501, Free PMC Article
  4. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. Potts PR, et al. EMBO J, 2006 Jul 26. PMID 16810316, Free PMC Article
  5. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Taylor EM, et al. Mol Cell Biol, 2008 Feb. PMID 18086888, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC114542

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular senescence IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Smc5-Smc6 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Smc5-Smc6 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase NSE2
Names
E3 SUMO-protein transferase NSE2
MMS21 homolog
non-SMC element 2 homolog
non-SMC element 2, MMS21 homolog
non-structural maintenance of chromosomes element 2 homolog
NP_001020047.1
XP_006241733.1
XP_017450247.1
XP_017450249.1
XP_038934723.1
XP_038934726.1
XP_038934727.1
XP_063119329.1
XP_063119330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024876.1 → NP_001020047.1  E3 SUMO-protein ligase NSE2

    See identical proteins and their annotated locations for NP_001020047.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097477
    UniProtKB/Swiss-Prot
    Q4V8A0
    UniProtKB/TrEMBL
    A0A0G2JW49, A6HRM3
    Related
    ENSRNOP00000005376.4, ENSRNOT00000005376.7
    Conserved Domains (1) summary
    cd16651
    Location:167 → 236
    SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    92825568..93071037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078795.2 → XP_038934723.1  E3 SUMO-protein ligase NSE2 isoform X3

    Conserved Domains (1) summary
    cd16651
    Location:133 → 202
    SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

  2. XM_017594758.3 → XP_017450247.1  E3 SUMO-protein ligase NSE2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A069, A6HRM2
    Related
    ENSRNOP00000085874.1, ENSRNOT00000099968.2
    Conserved Domains (1) summary
    pfam11789
    Location:182 → 242
    zf-Nse; Zinc-finger of the MIZ type in Nse subunit

  3. XM_063263259.1 → XP_063119329.1  E3 SUMO-protein ligase NSE2 isoform X2

  4. XM_039078798.2 → XP_038934726.1  E3 SUMO-protein ligase NSE2 isoform X6

    UniProtKB/TrEMBL
    A6HRM4

  5. XM_017594760.3 → XP_017450249.1  E3 SUMO-protein ligase NSE2 isoform X4

  6. XM_063263260.1 → XP_063119330.1  E3 SUMO-protein ligase NSE2 isoform X5

  7. XM_006241671.4 → XP_006241733.1  E3 SUMO-protein ligase NSE2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AS08
    Related
    ENSRNOP00000097544.1, ENSRNOT00000102133.2

  8. XM_039078799.2 → XP_038934727.1  E3 SUMO-protein ligase NSE2 isoform X7

RNA

  1. XR_010052954.1 RNA Sequence

  2. XR_010052955.1 RNA Sequence

  3. XR_001838681.3 RNA Sequence

  4. XR_005486582.2 RNA Sequence

    Related
    ENSRNOT00000086039.3

  5. XR_010052956.1 RNA Sequence

  6. XR_010052958.1 RNA Sequence

  7. XR_010052957.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8A0.1 GenPept UniProtKB/Swiss-Prot:Q4V8A0

Gene LinkOut

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