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Tle6 TLE family member 6, subcortical maternal complex member [ Rattus norvegicus (Norway rat) ]

Gene ID: 299637, updated on 2-Nov-2024

Summary

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Official Symbol
Tle6provided by RGD
Official Full Name
TLE family member 6, subcortical maternal complex memberprovided by RGD
Primary source
RGD:1561530
See related
EnsemblRapid:ENSRNOG00000006350 AllianceGenome:RGD:1561530
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561530
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in several processes, including cytoskeleton organization; embryonic process involved in female pregnancy; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Predicted to be located in cell cortex. Predicted to be part of subcortical maternal complex and transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 13.9), Kidney (RPKM 8.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tle6 in Genome Data Viewer
Location:
7q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8757846..8769405)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8107050..8118639)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (10964136..10988127)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551996 Neighboring gene sirtuin 6 Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene TLE family member 5, transcriptional modulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TLE6 mutation causes the earliest known human embryonic lethality. Alazami AM, et al. Genome Biol, 2015 Nov 5. PMID 26537248, Free PMC Article
  2. Distribution of RNA binding protein MOEP19 in the oocyte cortex and early embryo indicates pre-patterning related to blastomere polarity and trophectoderm specification. Herr JC, et al. Dev Biol, 2008 Feb 15. PMID 18191828, Free PMC Article
  3. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Li L, et al. Dev Cell, 2008 Sep. PMID 18804437, Free PMC Article
  4. Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Marçal N, et al. Mol Cell Biol, 2005 Dec. PMID 16314515, Free PMC Article
  5. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Zheng P, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19376971, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum localization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of spindle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogonial cell division ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of subcortical maternal complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 6
Names
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8757846..8769405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080433.2 → XP_038936361.1  transducin-like enhancer protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVQ7
    Conserved Domains (2) summary
    sd00039
    Location:252 → 306
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:251 → 538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006241027.4 → XP_006241089.2  transducin-like enhancer protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVQ7
    Conserved Domains (2) summary
    sd00039
    Location:252 → 306
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:251 → 538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006241030.5 → XP_006241092.2  transducin-like enhancer protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVQ7
    Related
    ENSRNOP00000008360.9, ENSRNOT00000008360.10
    Conserved Domains (2) summary
    sd00039
    Location:226 → 280
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:225 → 512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_063264486.1 → XP_063120556.1  transducin-like enhancer protein 6 isoform X3

    Related
    ENSRNOP00000081779.1, ENSRNOT00000109747.2

  5. XM_063264487.1 → XP_063120557.1  transducin-like enhancer protein 6 isoform X3

  6. XM_017595153.3 → XP_017450642.2  transducin-like enhancer protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZVQ7
    Conserved Domains (2) summary
    sd00039
    Location:209 → 263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:208 → 495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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