U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mknk2 MAPK interacting serine/threonine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299618, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Mknk2provided by RGD
Official Full Name
MAPK interacting serine/threonine kinase 2provided by RGD
Primary source
RGD:1305728
See related
EnsemblRapid:ENSRNOG00000029028 AllianceGenome:RGD:1305728
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; calmodulin binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to arsenic-containing substance; intracellular signal transduction; and protein phosphorylation. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK2 (MAPK interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 360.3), Spleen (RPKM 304.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mknk2 in Genome Data Viewer
Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9690385..9701527)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9039771..9050832)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11908107..11919161)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093774 Neighboring gene MOB kinase activator 3A Neighboring gene SUMO-conjugating enzyme UBC9-B-like Neighboring gene BTB domain containing 2 Neighboring gene casein kinase 1, gamma 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. Dolniak B, et al. J Biol Chem, 2008 May 2. PMID 18299328, Free PMC Article
  2. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Knauf U, et al. Mol Cell Biol, 2001 Aug. PMID 11463832, Free PMC Article
  3. Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. Joshi S, et al. J Biol Chem, 2011 Feb 25. PMID 21149447, Free PMC Article
  4. Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Chrestensen CA, et al. Genes Cells, 2007 Oct. PMID 17903173
  5. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M. Nat Rev Mol Cell Biol, 2006 Feb. PMID 16421520

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 2
Names
MAP kinase signal-integrating kinase 2
MAP kinase-interacting serine/threonine kinase 2
MAPK signal-integrating kinase 2
mnk2
NP_001011985.1
XP_063119244.1
XP_063119245.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011985.2 → NP_001011985.1  MAP kinase-interacting serine/threonine-protein kinase 2

    See identical proteins and their annotated locations for NP_001011985.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q5U2N4
    UniProtKB/TrEMBL
    A0A8I6AI16, A6K8I1
    Conserved Domains (2) summary
    smart00220
    Location:83 → 368
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:81 → 368
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9690385..9701527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263174.1 → XP_063119244.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2N4
    UniProtKB/TrEMBL
    A6K8I1
    Related
    ENSRNOP00000108798.1, ENSRNOT00000140938.1

  2. XM_063263175.1 → XP_063119245.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    Related
    ENSRNOP00000039672.4, ENSRNOT00000041106.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2N4.1 GenPept UniProtKB/Swiss-Prot:Q5U2N4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools