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NRBP1 nuclear receptor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 29959, updated on 3-Apr-2024

Summary

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Official Symbol
NRBP1provided by HGNC
Official Full Name
nuclear receptor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7993
See related
Ensembl:ENSG00000115216 MIM:606010; AllianceGenome:HGNC:7993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MADM; NRBP; BCON3; MUDPNP
Summary
Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues See more
Orthologs
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Genomic context

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See NRBP1 in Genome Data Viewer
Location:
2p23.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27427790..27442259)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27470161..27484612)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27650657..27665126)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27601343-27602213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11297 Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27618171-27618672 Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27665383-27665925 Neighboring gene keratinocyte associated protein 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27676057-27677256 Neighboring gene intraflagellar transport 172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27681686-27682885 Neighboring gene RNA, U6 small nuclear 986, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer. Yang X, et al. Oncogene, 2023 Mar. PMID 36693952, Free PMC Article
  2. Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer. Liao Y, et al. Cell Death Dis, 2018 Apr 1. PMID 29567997, Free PMC Article
  3. Design, virtual screening and docking study of novel NS3 inhibitors by targeting protein-protein interacting sites of dengue virus - a novel approach. Parida P, et al. Curr Pharm Biotechnol, 2013. PMID 24372240
  4. High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth. Ruiz C, et al. Prostate, 2012 Nov. PMID 22473923
  5. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. Hooper JD, et al. Genomics, 2000 May 15. PMID 10843813

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.
    Title: The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.
  2. The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
    Title: The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
  3. Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.
    Title: Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.
  4. CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.
    Title: CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.
  5. NRBP1-Containing CRL2/CRL4A Regulates Amyloid beta Production by Targeting BRI2 and BRI3 for Degradation.
    Title: NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.
  6. THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.
    Title: THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.
  7. Overexpression of NRBP1 triggers the activation of caspase-dependent intrinsic apoptosis, which promotes colorectal cancer cell apoptosis and inhibits cell proliferation and colony formation. High NRBP1 expression levels are associated with longer overall survival and disease-free survival.
    Title: Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer.
  8. Study have identified a gout risk gene, NRBP1,and demonstrated that increased NRBP1 expression in gout patients may be regulated through methylation-dependent binding of TFAP2A to the B1 region, a 72 bp upstream of NRBP1 transcription start site.
    Title: DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding.
  9. The present study deals with the molecular modeling of the viral protein (NS3 of DENV1-4), the host protein (NRBP) and their interactions through protein-protein docking study.
    Title: Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes.
  10. Targeting this we performed homology modeling and protein-protein docking study of NS3 with NRBP (Nuclear Receptor Binding Protein) of human as it has been proved that NS3 of DENV interacts with NRBP which causes cellular trafficking in human cell.
    Title: Design, virtual screening and docking study of novel NS3 inhibitors by targeting protein-protein interacting sites of dengue virus - a novel approach.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of nuclear receptor binding protein 1 (NRBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NRBP1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27109, FLJ35541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nuclear receptor-binding protein
Names
multiple domain putative nuclear protein
myeloid leukemia factor 1 adaptor molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321357.2 → NP_001308286.1  nuclear receptor-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074117, AK122664, BC001221
    Consensus CDS
    CCDS1753.1
    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
    UniProtKB/TrEMBL
    B4DW31
    Related
    ENSP00000233557.3, ENST00000233557.7
    Conserved Domains (1) summary
    cd14034
    Location:60 → 334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

  2. NM_001321358.2 → NP_001308287.1  nuclear receptor-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    Consensus CDS
    CCDS82433.1
    UniProtKB/TrEMBL
    B4DW31, F8W6G1
    Conserved Domains (1) summary
    cd14034
    Location:60 → 342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

  3. NM_001321359.2 → NP_001308288.1  nuclear receptor-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    Consensus CDS
    CCDS82433.1
    UniProtKB/TrEMBL
    B4DW31, F8W6G1
    Related
    ENSP00000369192.3, ENST00000379863.7
    Conserved Domains (1) summary
    cd14034
    Location:60 → 342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

  4. NM_001321361.2 → NP_001308290.1  nuclear receptor-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/TrEMBL
    B4DW31
    Conserved Domains (2) summary
    smart00220
    Location:83 → 332
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14034
    Location:60 → 341
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

  5. NM_001321362.2 → NP_001308291.1  nuclear receptor-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/TrEMBL
    B4DW31
    Conserved Domains (1) summary
    cd14034
    Location:60 → 333
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

  6. NM_001321363.2 → NP_001308292.1  nuclear receptor-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/TrEMBL
    B4DW31
    Conserved Domains (1) summary
    cl21453
    Location:60 → 302
    PKc_like; Protein Kinases, catalytic domain

  7. NM_013392.4 → NP_037524.1  nuclear receptor-binding protein isoform 1

    See identical proteins and their annotated locations for NP_037524.1

    Status: VALIDATED

    Source sequence(s)
    BC001221, BQ949042
    Consensus CDS
    CCDS1753.1
    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
    UniProtKB/TrEMBL
    B4DW31
    Related
    ENSP00000369181.3, ENST00000379852.8
    Conserved Domains (1) summary
    cd14034
    Location:60 → 334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27427790..27442259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444036.1 → XP_047299992.1  nuclear receptor-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27470161..27484612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341567.1 → XP_054197542.1  nuclear receptor-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHY1.1 GenPept UniProtKB/Swiss-Prot:Q9UHY1

Gene LinkOut

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