U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HILPDA hypoxia inducible lipid droplet associated [ Homo sapiens (human) ]

Gene ID: 29923, updated on 10-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
HILPDAprovided by HGNC
Official Full Name
hypoxia inducible lipid droplet associatedprovided by HGNC
Primary source
HGNC:HGNC:28859
See related
Ensembl:ENSG00000135245 MIM:617905; AllianceGenome:HGNC:28859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIG2; HIG-2; C7orf68
Summary
Enables signaling receptor binding activity. Involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Located in several cellular components, including cell surface; lipid droplet; and secretory granule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 37.4), fat (RPKM 20.9) and 20 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (128455878..128458418)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (129767662..129770201)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128095932..128098472)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37 pseudogene 16 Neighboring gene RNA, U7 small nuclear 54 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:128093960-128094666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18608 Neighboring gene Sharpr-MPRA regulatory region 9446 Neighboring gene EFCAB3 pseudogene 1 Neighboring gene EFCAB3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26601 Neighboring gene methyltransferase 2B, tRNA N3-cytidine Neighboring gene MPRA-validated peak6715 silencer

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors. VandeKopple MJ, et al. Mol Cancer Res, 2019 Oct. PMID 31308147, Free PMC Article
  2. Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase. Padmanabha Das KM, et al. J Lipid Res, 2018 Mar. PMID 29326160, Free PMC Article
  3. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma. Mao XG, et al. Oncotarget, 2016 Jul 26. PMID 27329597, Free PMC Article
  4. Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer. Nishimura S, et al. Eur J Gynaecol Oncol, 2011. PMID 21614900
  5. Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. Nishimura S, et al. Int J Gynecol Cancer, 2010 Feb. PMID 20134266

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma.
    Title: Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma.
  2. HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia.
    Title: HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia.
  3. HILPDA-mediated lipidomic remodelling promotes radiotherapy resistance in nasopharyngeal carcinoma by accelerating mitophagy.
    Title: HILPDA-mediated lipidomic remodelling promotes radiotherapy resistance in nasopharyngeal carcinoma by accelerating mitophagy.
  4. IRF1 promotes the chondrogenesis of human adipose-derived stem cells through regulating HILPDA.
    Title: IRF1 promotes the chondrogenesis of human adipose-derived stem cells through regulating HILPDA.
  5. Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis.
    Title: Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis.
  6. Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer.
    Title: Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer.
  7. Lipidomic analysis revealed not only quantitative but also qualitative differences in the glycerolipid and phospholipid profile of HILPDA wild-type and knockout cells, indicating additional HILPDA functions affecting lipid metabolism.
    Title: HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors.
  8. HIG2 activates the STAT3 signaling pathway in NK cells by promoting IL-10 release by HCC cells, thereby inhibiting the killing activity of NK cells, and subsequently promoting the recurrence and metastasis of HCC.
    Title: Hypoxia-inducible gene 2 promotes the immune escape of hepatocellular carcinoma from nature killer cells through the interleukin-10-STAT3 signaling pathway.
  9. Expression changes in secreted frizzled-related protein 2, stearoyl-CoA desaturase, and hypoxia inducible lipid droplet-associated (HILPDA) with weight loss were confirmed by reverse transcription quantitative polymerase chain reaction. Dietary weight loss induces significant changes in the expression of genes implicated in lipid metabolism (SCD and HILPDA) and WNT-signaling (SFRP2) in subcutaneous adipose tissue.
    Title: Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss.
  10. hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase
    Title: Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of hypoxia inducible lipid droplet-associated protein (HILPDA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ21076, MGC138388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autocrine signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autocrine signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
hypoxia-inducible lipid droplet-associated protein
Names
hypoxia inducible gene 2
hypoxia-inducible gene 2 protein
hypoxia-inducible protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098786.2 → NP_001092256.1  hypoxia-inducible lipid droplet-associated protein

    See identical proteins and their annotated locations for NP_001092256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF144755, AL691669, BC008573, CX784347
    Consensus CDS
    CCDS5802.1
    UniProtKB/Swiss-Prot
    A4D0Z5, Q52LY5, Q53HJ7, Q9Y5L2
    Related
    ENSP00000388871.2, ENST00000435296.2
    Conserved Domains (1) summary
    pfam15220
    Location:1 → 63
    HILPDA; Hypoxia-inducible lipid droplet-associated

  2. NM_013332.4 → NP_037464.1  hypoxia-inducible lipid droplet-associated protein

    See identical proteins and their annotated locations for NP_037464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF144755, BC001863, BC008573, CD686848
    Consensus CDS
    CCDS5802.1
    UniProtKB/Swiss-Prot
    A4D0Z5, Q52LY5, Q53HJ7, Q9Y5L2
    Related
    ENSP00000257696.4, ENST00000257696.5
    Conserved Domains (1) summary
    pfam15220
    Location:1 → 63
    HILPDA; Hypoxia-inducible lipid droplet-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    128455878..128458418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    129767662..129770201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5L2.1 GenPept UniProtKB/Swiss-Prot:Q9Y5L2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous