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Eif2s3 eukaryotic translation initiation factor 2 subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 299027, updated on 2-Nov-2024

Summary

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Official Symbol
Eif2s3provided by RGD
Official Full Name
eukaryotic translation initiation factor 2 subunit gammaprovided by RGD
Primary source
RGD:1561279
See related
EnsemblRapid:ENSRNOG00000060793 AllianceGenome:RGD:1561279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PP42; Eif2g; Eif2s3x
Summary
Predicted to enable methionyl-initiator methionine tRNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in synapse. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 486.7), Spleen (RPKM 468.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif2s3 in Genome Data Viewer
Location:
Xq22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62910292..62933936, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58916513..58939923, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63268106..63291125, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein X-linked Neighboring gene uncharacterized LOC134484053 Neighboring gene uncharacterized LOC134484164 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat liver pp49, a protein that forms complexes with protein kinase CK2, is composed of the beta and the gamma subunits of translation initiation factor eIF-2. Gil C, et al. Biochem Biophys Res Commun, 1996 Aug 23. PMID 8780732
  2. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, et al. Eur J Biochem, 1988 Mar 15. PMID 2450747
  3. Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. Kruger M, et al. Proc Natl Acad Sci U S A, 2000 Jul 18. PMID 10900014, Free PMC Article
  4. eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. Borck G, et al. Mol Cell, 2012 Nov 30. PMID 23063529, Free PMC Article
  5. Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Young-Baird SK, et al. Mol Cell, 2020 Feb 20. PMID 31836389, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionyl-initiator methionine tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 subunit 3, X-linked
Names
eIF-2-gamma X
eIF2-gamma
eIF2-gamma X
eukaryotic translation initiation factor 2 subunit gamma, X-linked
eukaryotic translation initiation factor 2, subunit 3 gamma
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
NP_001094012.1
XP_063135947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100542.1 → NP_001094012.1  eukaryotic translation initiation factor 2 subunit 3, X-linked

    See identical proteins and their annotated locations for NP_001094012.1

    Status: VALIDATED

    Source sequence(s)
    AI029347, BC091286, BC166783, BM392036, EV772689
    UniProtKB/Swiss-Prot
    B0BN96, B2RYH8, P81795, Q5BJX8
    UniProtKB/TrEMBL
    A0A8L2R4R9
    Related
    ENSRNOP00000070817.3, ENSRNOT00000092019.3
    Conserved Domains (1) summary
    PTZ00327
    Location:13 → 466
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    62910292..62933936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279877.1 → XP_063135947.1  eukaryotic translation initiation factor 2 subunit 3, X-linked isoform X1

    UniProtKB/Swiss-Prot
    B0BN96, B2RYH8, P81795, Q5BJX8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81795.2 GenPept UniProtKB/Swiss-Prot:P81795

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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