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Atl2 atlastin GTPase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298757, updated on 28-Oct-2024

Summary

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Official Symbol
Atl2provided by RGD
Official Full Name
atlastin GTPase 2provided by RGD
Primary source
RGD:1305125
See related
EnsemblRapid:ENSRNOG00000006523 AllianceGenome:RGD:1305125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arl6ip2
Summary
Predicted to enable GTP binding activity; GTPase activity; and identical protein binding activity. Predicted to be involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum tubular network membrane. Orthologous to human ATL2 (atlastin GTPase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 456.2), Liver (RPKM 345.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atl2 in Genome Data Viewer
Location:
6q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20891220..20932644)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (15139071..15180421)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2568975..2610432)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479323 Neighboring gene uncharacterized LOC134479324 Neighboring gene uncharacterized LOC108351158 Neighboring gene uncharacterized LOC102554703 Neighboring gene uncharacterized LOC134479104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. Rismanchi N, et al. Hum Mol Genet, 2008 Jun 1. PMID 18270207, Free PMC Article
  2. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Wang S, et al. Elife, 2016 Sep 13. PMID 27619977, Free PMC Article
  3. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Hu J, et al. Cell, 2009 Aug 7. PMID 19665976, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum tubular network membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atlastin-2
Names
ADP-ribosylation factor-like 6 interacting protein 2
NP_001094141.1
XP_063117669.1
XP_063117670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100671.1 → NP_001094141.1  atlastin-2

    Status: VALIDATED

    Source sequence(s)
    BC092650, CB580536, CO395790, EV762626
    UniProtKB/TrEMBL
    F1LQ09
    Related
    ENSRNOP00000106218.1, ENSRNOT00000172058.1
    Conserved Domains (1) summary
    pfam02263
    Location:70 → 341
    GBP; Guanylate-binding protein, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20891220..20932644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261599.1 → XP_063117669.1  atlastin-2 isoform X1

  2. XM_063261600.1 → XP_063117670.1  atlastin-2 isoform X2

    Related
    ENSRNOP00000071967.2, ENSRNOT00000077543.3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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