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Pde7b phosphodiesterase 7B [ Mus musculus (house mouse) ]

Gene ID: 29863, updated on 2-Nov-2024

Summary

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Official Symbol
Pde7bprovided by MGI
Official Full Name
phosphodiesterase 7Bprovided by MGI
Primary source
MGI:MGI:1352752
See related
Ensembl:ENSMUSG00000019990 AllianceGenome:MGI:1352752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; heart; integumental system; liver; and sensory organ. Orthologous to human PDE7B (phosphodiesterase 7B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 2.7), lung adult (RPKM 2.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Pde7b in Genome Data Viewer
Location:
10 A3; 10 9.75 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20272798..20600824, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20397052..20725078, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6822 Neighboring gene STARR-seq mESC enhancer starr_25963 Neighboring gene mitochondrial fission regulator 2 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25964 Neighboring gene VISTA enhancer mm140 Neighboring gene STARR-positive B cell enhancer ABC_E1796 Neighboring gene STARR-seq mESC enhancer starr_25965 Neighboring gene F-box protein 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25966 Neighboring gene STARR-seq mESC enhancer starr_25967 Neighboring gene STARR-seq mESC enhancer starr_25968 Neighboring gene MYB binding protein (P160) 1a pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:20491677-20491977 Neighboring gene STARR-seq mESC enhancer starr_25969 Neighboring gene STARR-seq mESC enhancer starr_25970 Neighboring gene STARR-positive B cell enhancer mm9_chr10:20554956-20555257 Neighboring gene predicted gene, 33510 Neighboring gene predicted gene, 53617 Neighboring gene ribosomal protein S2, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. Morales-Garcia JA, et al. Neurobiol Aging, 2015 Feb. PMID 25457552
  2. Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma. Chevalier E, et al. Eur Respir J, 2012 Mar. PMID 22088971
  3. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Hetman JM, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618442, Free PMC Article
  4. Identification of human PDE7B, a cAMP-specific phosphodiesterase. Sasaki T, et al. Biochem Biophys Res Commun, 2000 May 19. PMID 10814504
  5. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Gardner C, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872825

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 7B
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
cAMP-specific phosphodiesterase 7B
NP_001334295.1
NP_038903.3
XP_036011699.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347366.1 → NP_001334295.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC153845, AJ251859, AK035385, AK049910, CX215057
    Consensus CDS
    CCDS83686.1
    UniProtKB/TrEMBL
    E9PW23, E9Q0W7
    Related
    ENSMUSP00000132378.2, ENSMUST00000169404.8

  2. NM_013875.6 → NP_038903.3  3',5'-cyclic-AMP phosphodiesterase 7B isoform 2

    See identical proteins and their annotated locations for NP_038903.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and and contains alternate exons in the 5' coding region, compared to variant 1. These differences cause translation initiation at am alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC153845, AJ251859, AK035385, BB627693, CX215057
    Consensus CDS
    CCDS35859.1
    UniProtKB/Swiss-Prot
    A1L3T2, Q9QXQ1
    UniProtKB/TrEMBL
    Q8CBS2
    Related
    ENSMUSP00000020165.8, ENSMUST00000020165.14
    Conserved Domains (1) summary
    pfam00233
    Location:172 → 392
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    20272798..20600824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155806.1 → XP_036011699.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:65 → 299
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXQ1.1 GenPept UniProtKB/Swiss-Prot:Q9QXQ1

Gene LinkOut

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