C1qa complement C1q A chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qaprovided by RGD
Official Full Name: complement C1q A chainprovided by RGD
Primary source: RGD:1306716
See related: EnsemblRapid:ENSRNOG00000012807 AllianceGenome:RGD:1306716
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adic
Summary: Involved in response to iron ion. Located in synapse. Biomarker of iron deficiency anemia. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human C1QA (complement C1q A chain). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 2171.2), Liver (RPKM 544.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154417086..154419933, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149133635..149136482, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155261254..155264101, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that complement C1q expression may play a principal role in hepatic ischemia-reperfusion (I/R) injury, particularly at the early stage of perfusion.
Title: Effect of complement C1q expression on hepatic ischemia-reperfusion injury in rats.
C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129734 (e-PCR)
- UniSTS:213027

AI255395 (e-PCR)
- UniSTS:179092

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in astrocyte activation	IEA Inferred from Electronic Annotation more info
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in complement-mediated synapse pruning	IEA Inferred from Electronic Annotation more info
involved_in complement-mediated synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in vertebrate eye-specific patterning	IEA Inferred from Electronic Annotation more info
involved_in vertebrate eye-specific patterning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of complement component C1q complex	IEA Inferred from Electronic Annotation more info
part_of complement component C1q complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q subcomponent subunit A

Names: adiponectin c; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008515.1 → NP_001008515.1 complement C1q subcomponent subunit A precursor

See identical proteins and their annotated locations for NP_001008515.1

Status: PROVISIONAL

Source sequence(s)

BC086605

UniProtKB/Swiss-Prot

P31720, Q5RJK1

UniProtKB/TrEMBL

A0A3B0J380, A6ITC6

Related

ENSRNOP00000017385.3, ENSRNOT00000017385.8

Conserved Domains (2) summary

smart00110
Location:108 → 244

C1Q; Complement component C1q domain

pfam01391
Location:40 → 96

Collagen; Collagen triple helix repeat (20 copies)