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Rragc Ras-related GTP binding C [ Rattus norvegicus (Norway rat) ]

Gene ID: 298514, updated on 2-Nov-2024

Summary

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Official Symbol
Rragcprovided by RGD
Official Full Name
Ras-related GTP binding Cprovided by RGD
Primary source
RGD:1311760
See related
EnsemblRapid:ENSRNOG00000017426 AllianceGenome:RGD:1311760
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGC (Ras related GTP binding C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 139.4), Spleen (RPKM 126.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rragc in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (141433014..141452546)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (136148239..136167773)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (141572536..141590784)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479028 Neighboring gene Myc binding protein Neighboring gene uncharacterized LOC120102974 Neighboring gene long non-coding RNA 081

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype. Larsen M, et al. Eur J Hum Genet, 2016 Oct. PMID 27222292, Free PMC Article
  2. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. Sekiguchi T, et al. J Biol Chem, 2001 Mar 9. PMID 11073942
  3. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
  4. Molecular mechanisms of mTOR-mediated translational control. Ma XM, et al. Nat Rev Mol Cell Biol, 2009 May. PMID 19339977
  5. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Han JM, et al. Cell, 2012 Apr 13. PMID 22424946

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amino acid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
  
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related GTP-binding protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048184.1 → NP_001041649.1  ras-related GTP-binding protein C

    See identical proteins and their annotated locations for NP_001041649.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105622
    UniProtKB/TrEMBL
    A6IS39, Q0D2L6
    Related
    ENSRNOP00000023514.5, ENSRNOT00000023514.7
    Conserved Domains (1) summary
    cd11385
    Location:62 → 236
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    141433014..141452546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109616.2 → XP_038965544.1  ras-related GTP-binding protein C isoform X1

    UniProtKB/TrEMBL
    A6IS39
    Conserved Domains (1) summary
    cd11385
    Location:62 → 236
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
Nucleotide Protein Strain
Heading Accession and Version

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