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Efcab14 EF-hand calcium binding domain 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298425, updated on 2-Nov-2024

Summary

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Official Symbol
Efcab14provided by RGD
Official Full Name
EF-hand calcium binding domain 14provided by RGD
Primary source
RGD:1310351
See related
EnsemblRapid:ENSRNOG00000010091 AllianceGenome:RGD:1310351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310351
Summary
Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Orthologous to human EFCAB14 (EF-hand calcium binding domain 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 180.9), Kidney (RPKM 174.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Efcab14 in Genome Data Viewer
Location:
5q35
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134454908..134493714)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129218139..129258628)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134594012..134632168)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1 Neighboring gene farnesyl diphosphate synthase, pseudogene 2 Neighboring gene uncharacterized LOC134487082 Neighboring gene testis expressed 38 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106677.2 → NP_001100147.1  EF-hand calcium-binding domain-containing protein 14

    See identical proteins and their annotated locations for NP_001100147.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AQN0, A6JZ45, D3ZTM7
    Related
    ENSRNOP00000013471.5, ENSRNOT00000013471.9
    Conserved Domains (2) summary
    COG1196
    Location:97 → 344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl08302
    Location:427 → 478
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134454908..134493714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287401.1 → XP_063143471.1  EF-hand calcium-binding domain-containing protein 14 isoform X1

  2. XM_039109592.2 → XP_038965520.1  EF-hand calcium-binding domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLM3, A0A8I6AQN0
    Related
    ENSRNOP00000078819.1, ENSRNOT00000100267.2
    Conserved Domains (2) summary
    COG1196
    Location:97 → 344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl08302
    Location:427 → 478
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version

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