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Slc6a14 solute carrier family 6 member 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298340, updated on 10-Jul-2024

Summary

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Official Symbol
Slc6a14provided by RGD
Official Full Name
solute carrier family 6 member 14provided by RGD
Primary source
RGD:1561810
See related
EnsemblRapid:ENSRNOG00000005687 AllianceGenome:RGD:1561810
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atb0+
Summary
Predicted to enable alanine transmembrane transporter activity. Predicted to be involved in amino acid transport; response to toxic substance; and sodium ion transmembrane transport. Located in brush border membrane. Biomarker of inflammatory bowel disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 253.7) See more
Orthologs
human mouse all
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Genomic context

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See Slc6a14 in Genome Data Viewer
Location:
Xq34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (117109063..117169522)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (112314643..112375412)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (120624522..120647964)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorbitol dehydrogenase, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene SIN3-HDAC complex associated factor, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier. Michalec K, et al. Arch Biochem Biophys, 2014 Jul 15. PMID 24823859
  2. Protein kinase C regulates amino acid transporter ATB(0,+). Samluk L, et al. Biochem Biophys Res Commun, 2012 May 25. PMID 22561015
  3. Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. Uchiyama T, et al. J Cell Physiol, 2008 Mar. PMID 17960566
  4. Stimulation of expression of the intestinal glutamine transporter ATB0 in tumor-bearing rats. Choudry HA, et al. Ann Surg Oncol, 2006 Dec. PMID 17006743
  5. Stimulation of intestinal glutamine absorption in chronic metabolic acidosis. Pan M, et al. Surgery, 2004 Aug. PMID 15300171

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The analyses of brain slices demonstrated ATB(0,+) luminal localization in brain capillaries, confirmed by biotinylation experiments in an in vitro model of the blood-brain barrier.
    Title: Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier.
  2. The observed regulation of ATB(0,+) by PKC correlates with high activity of both proteins reported for cancer cells.
    Title: Protein kinase C regulates amino acid transporter ATB(0,+).
  3. Rat pneumocytes express ATB(0,+), which may partly contribute towards recovering cationic and neutral amino acids from alveolar luminal fluid.
    Title: Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.
  4. The role of carnitine in inflammatory bowel disease (IBD)was evaluated using the expression of the carnitine transporters OCTN2 and ATB0+, and butyrate metabolism in colonocytes in a rat model of IBD.
    Title: Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables (R)-carnitine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (R)-carnitine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables branched-chain amino acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables branched-chain amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral, basic amino acid:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral, basic amino acid:sodium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in (R)-carnitine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in (R)-carnitine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in alanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in aromatic amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in beta-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in beta-alanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in branched-chain amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Names
colonic system B0+ amino acid transporter
neutral cationic amino acid transporter B0,+
solute carrier family 6 (amino acid transporter), member 14
solute carrier family 6 (neurotransmitter transporter), member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037544.2 → NP_001032633.1  sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    See identical proteins and their annotated locations for NP_001032633.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6GLX0, Q334I2
    Related
    ENSRNOP00000007967.5, ENSRNOT00000007967.8
    Conserved Domains (1) summary
    cd11501
    Location:36 → 639
    SLC6sbd_ATB0; Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    117109063..117169522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099573.2 → XP_038955501.1  sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5L0, A0A8I6GLX0
    Related
    ENSRNOP00000087988.1, ENSRNOT00000115597.2
    Conserved Domains (1) summary
    cd11501
    Location:42 → 645
    SLC6sbd_ATB0; Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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