C8a complement C8 alpha chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C8aprovided by RGD
Official Full Name: complement C8 alpha chainprovided by RGD
Primary source: RGD:1308355
See related: EnsemblRapid:ENSRNOG00000007697 AllianceGenome:RGD:1308355
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables complement binding activity. Predicted to be involved in complement activation, classical pathway; cytolysis; and innate immune response. Predicted to act upstream of or within complement activation. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in type I complement component 8 deficiency. Orthologous to human C8A (complement C8 alpha chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 2545.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (124812131..124866631, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (119583168..119637675, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (124348536..124403117, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
Title: Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130236 (e-PCR)
- UniSTS:213523

D5Rhm4 (e-PCR)
- UniSTS:517849

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane attack complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C8 alpha chain

Names: complement component 8 alpha subunit; complement component 8, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106670.1 → NP_001100140.1 complement component C8 alpha chain precursor

See identical proteins and their annotated locations for NP_001100140.1

Status: PROVISIONAL

Source sequence(s)

CH473998

UniProtKB/TrEMBL

A6JRT8, D3ZWD6

Related

ENSRNOP00000063871.3, ENSRNOT00000067850.4

Conserved Domains (4) summary

smart00209
Location:545 → 587

TSP1; Thrombospondin type 1 repeats

smart00457
Location:289 → 492

MACPF; membrane-attack complex / perforin

pfam00057
Location:95 → 130

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl15697
Location:237 → 293

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains