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ZDHHC1 zinc finger DHHC-type containing 1 [ Homo sapiens (human) ]

Gene ID: 29800, updated on 7-Apr-2024

Summary

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Official Symbol
ZDHHC1provided by HGNC
Official Full Name
zinc finger DHHC-type containing 1provided by HGNC
Primary source
HGNC:HGNC:17916
See related
Ensembl:ENSG00000159714 AllianceGenome:HGNC:17916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC-1; ZNF377; C16orf1; HSU90653
Summary
Enables palmitoyltransferase activity. Involved in antiviral innate immune response; positive regulation of defense response to virus by host; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
16q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67394152..67416477, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73188923..73211253, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67428055..67450380, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene tubulin polymerization promoting protein family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67454837-67455408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67458128-67458722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67461918-67462452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67462453-67462987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67469389-67469890 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67477413-67478036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67478661-67479284 Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67481159-67481658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67485489-67486172 Neighboring gene Sharpr-MPRA regulatory region 10086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67495532-67496032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499338-67499838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499839-67500339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10966

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis. Le X, et al. Theranostics, 2020. PMID 32863941, Free PMC Article
  2. The DHHC domain: a new highly conserved cysteine-rich motif. Putilina T, et al. Mol Cell Biochem, 1999 May. PMID 10395086
  3. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. Wang X, et al. PLoS Pathog, 2020 Oct. PMID 33108395, Free PMC Article
  4. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Zhou Q, et al. Cell Host Microbe, 2014 Oct 8. PMID 25299331
  5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
    Title: DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
  2. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
    Title: p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
  3. In an expression screen for proteins that can activate the IFNB1 promoter, authors identified the ER-associated protein ZDHHC1 as a positive regulator of virus-triggered, MITA/STING-dependent immune signaling.
    Title: The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.
  4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide searching of rare genetic variants in WTCCC data.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
palmitoyltransferase ZDHHC1
Names
DHHC domain-containing cysteine-rich protein 1
probable palmitoyltransferase ZDHHC1
zinc finger DHHC domain-containing protein 1
zinc finger protein 377
zinc finger, DHHC domain containing 1
NP_001310556.1
NP_037436.1
XP_006721248.1
XP_011521362.1
XP_024306013.1
XP_024306014.1
XP_024306015.1
XP_054236159.1
XP_054236160.1
XP_054236161.1
XP_054236162.1
XP_054236163.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323627.2 → NP_001310556.1  palmitoyltransferase ZDHHC1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009061, BM724650, BX111231, HY054038, U90653
    Consensus CDS
    CCDS92175.1
    UniProtKB/TrEMBL
    I3L202
    Related
    ENSP00000459264.2, ENST00000565726.3
    Conserved Domains (1) summary
    pfam01529
    Location:129 → 284
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_013304.3 → NP_037436.1  palmitoyltransferase ZDHHC1 isoform 1

    See identical proteins and their annotated locations for NP_037436.1

    Status: VALIDATED

    Source sequence(s)
    AC009061, BC021908, CA432496, U90653
    Consensus CDS
    CCDS10836.1
    UniProtKB/Swiss-Prot
    O15461, Q8WTX9
    Related
    ENSP00000340299.2, ENST00000348579.6
    Conserved Domains (1) summary
    pfam01529
    Location:129 → 284
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67394152..67416477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450247.2 → XP_024306015.1  palmitoyltransferase ZDHHC1 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:129 → 284
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_024450246.2 → XP_024306014.1  palmitoyltransferase ZDHHC1 isoform X3

    Conserved Domains (2) summary
    pfam01529
    Location:129 → 284
    zf-DHHC; DHHC palmitoyltransferase
    pfam03546
    Location:323 → 469
    Treacle; Treacher Collins syndrome protein Treacle

  3. XM_006721185.3 → XP_006721248.1  palmitoyltransferase ZDHHC1 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:129 → 284
    zf-DHHC; DHHC palmitoyltransferase

  4. XM_024450245.2 → XP_024306013.1  palmitoyltransferase ZDHHC1 isoform X1

    UniProtKB/Swiss-Prot
    O15461, Q8WTX9
    Conserved Domains (1) summary
    pfam01529
    Location:129 → 284
    zf-DHHC; DHHC palmitoyltransferase

  5. XM_011523060.2 → XP_011521362.1  palmitoyltransferase ZDHHC1 isoform X5

    Conserved Domains (1) summary
    pfam01529
    Location:44 → 199
    zf-DHHC; DHHC palmitoyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73188923..73211253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380187.1 → XP_054236162.1  palmitoyltransferase ZDHHC1 isoform X4

  2. XM_054380186.1 → XP_054236161.1  palmitoyltransferase ZDHHC1 isoform X3

  3. XM_054380185.1 → XP_054236160.1  palmitoyltransferase ZDHHC1 isoform X2

  4. XM_054380184.1 → XP_054236159.1  palmitoyltransferase ZDHHC1 isoform X1

    UniProtKB/Swiss-Prot
    O15461, Q8WTX9

  5. XM_054380188.1 → XP_054236163.1  palmitoyltransferase ZDHHC1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WTX9.1 GenPept UniProtKB/Swiss-Prot:Q8WTX9

Gene LinkOut

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