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Plag1 PLAG1 zinc finger [ Rattus norvegicus (Norway rat) ]

Gene ID: 297804, updated on 17-Aug-2024

Summary

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Official Symbol
Plag1provided by RGD
Official Full Name
PLAG1 zinc fingerprovided by RGD
Primary source
RGD:1305286
See related
EnsemblRapid:ENSRNOG00000008846 AllianceGenome:RGD:1305286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of glial cell proliferation and regulation of gene expression. Predicted to act upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 55.5), Thymus (RPKM 48.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plag1 in Genome Data Viewer
Location:
5q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21699650..21754325, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16902057..16956727, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16788186..16842827, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene ribosomal protein L19 like 4 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7 Neighboring gene short chain dehydrogenase/reductase family 16C, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway. Gu Q, et al. Folia Biol (Praha), 2022. PMID 36201855
  2. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Voz ML, et al. Cancer Res, 2000 Jan 1. PMID 10646861
  3. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Aström AK, et al. Cancer Res, 1999 Feb 15. PMID 10029085
  4. Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Hide T, et al. Cancer Res, 2009 Oct 15. PMID 19808959
  5. Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility. Hensen K, et al. Dev Growth Differ, 2004 Oct. PMID 15606491

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin Signalling Pathway.
    Title: PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94626

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within gland morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within organ growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostate gland growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein PLAG1
Names
pleiomorphic adenoma gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008316.2 → NP_001008317.1  zinc finger protein PLAG1

    See identical proteins and their annotated locations for NP_001008317.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q5U2T6
    UniProtKB/TrEMBL
    A6JFM0
    Related
    ENSRNOP00000011721.3, ENSRNOT00000011721.6
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    21699650..21754325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763525.4 → XP_008761747.1  zinc finger protein PLAG1 isoform X1

    See identical proteins and their annotated locations for XP_008761747.1

    UniProtKB/Swiss-Prot
    Q5U2T6
    UniProtKB/TrEMBL
    A6JFM0
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063287277.1 → XP_063143347.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2T6
    UniProtKB/TrEMBL
    A6JFM0

  3. XM_063287274.1 → XP_063143344.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2T6
    UniProtKB/TrEMBL
    A6JFM0

  4. XM_063287275.1 → XP_063143345.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2T6
    UniProtKB/TrEMBL
    A6JFM0

  5. XM_017593224.3 → XP_017448713.1  zinc finger protein PLAG1 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:10 → 58
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  6. XM_063287278.1 → XP_063143348.1  zinc finger protein PLAG1 isoform X2

  7. XM_063287276.1 → XP_063143346.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    Q5U2T6
    UniProtKB/TrEMBL
    A6JFM0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2T6.1 GenPept UniProtKB/Swiss-Prot:Q5U2T6

Gene LinkOut

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