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Ergic2 ERGIC and golgi 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297728, updated on 28-Oct-2024

Summary

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Official Symbol
Ergic2provided by RGD
Official Full Name
ERGIC and golgi 2provided by RGD
Primary source
RGD:1310606
See related
EnsemblRapid:ENSRNOG00000001852 AllianceGenome:RGD:1310606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310606
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and nucleolus. Predicted to be part of retrograde transporter complex, Golgi to ER. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Orthologous to human ERGIC2 (ERGIC and golgi 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Muscle (RPKM 325.1), Heart (RPKM 248.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ergic2 in Genome Data Viewer
Location:
4q44
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (182822225..182858392, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181090808..181123074, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (182569086..182600258, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486874 Neighboring gene uncharacterized LOC108350795 Neighboring gene fatty acyl CoA reductase 2 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1 Neighboring gene ribosomal protein S4, X-linked, pseudogene 13 Neighboring gene thymosin beta-10-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The possible interaction of CDA14 and protein elongation factor 1alpha. Yang YF, et al. Biochim Biophys Acta, 2008 Feb. PMID 17980171
  2. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Yu J, et al. Dev Cell, 2014 May 12. PMID 24768165
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of retrograde transporter complex, Golgi to ER ISO
Inferred from Sequence Orthology
more info
  
part_of transporter complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum-Golgi intermediate compartment protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394930.1 → NP_001381859.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JYN4, A6IN52
    Related
    ENSRNOP00000070726.1, ENSRNOT00000079291.3
    Conserved Domains (2) summary
    pfam07970
    Location:170 → 332
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:13 → 95
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  2. NM_001394931.1 → NP_001381860.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RNA

  1. NR_172212.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    182822225..182858392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285924.1 → XP_063141994.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYN4, A6IN52

  2. XM_063285922.1 → XP_063141992.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYN4, A6IN52

  3. XM_063285925.1 → XP_063141995.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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