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Ing4 inhibitor of growth family, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297597, updated on 18-Sep-2024

Summary

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Official Symbol
Ing4provided by RGD
Official Full Name
inhibitor of growth family, member 4provided by RGD
Primary source
RGD:1309407
See related
EnsemblRapid:ENSRNOG00000023363 AllianceGenome:RGD:1309407
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable methylated histone binding activity and transcription coactivator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; histone acetylation; and negative regulation of transcription, DNA-templated. Predicted to be located in cytosol; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human ING4 (inhibitor of growth family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 188.7), Lung (RPKM 158.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ing4 in Genome Data Viewer
Location:
4q42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159528183..159536762)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157841882..157850519)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157554729..157563353)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384 Neighboring gene uncharacterized LOC102554095 Neighboring gene acrosin binding protein Neighboring gene lysophosphatidic acid receptor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation. Zhang X, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517644, Free PMC Article
  2. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. Zhang X, et al. FEBS Lett, 2004 Jul 16. PMID 15251430
  3. Mouse ING1 homologue, a protein interacting with A1, enhances cell death and is inhibited by A1 in mammary epithelial cells. Ha S, et al. Cancer Res, 2002 Mar 1. PMID 11888890
  4. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Garkavtsev I, et al. Nature, 2004 Mar 18. PMID 15029197
  5. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Shiseki M, et al. Cancer Res, 2003 May 15. PMID 12750254

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. provide evidence for the role of ING4 in mediating the effect of low K intake on renal outer medullary K channel activity by stimulation of p38 and ERK mitogen-activated protein kinase
    Title: Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC156688

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
NOT contributes_to histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079887.1 → NP_001073356.1  inhibitor of growth protein 4

    See identical proteins and their annotated locations for NP_001073356.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127511
    UniProtKB/TrEMBL
    A1L130, A6ILQ5, F1LLY0
    Conserved Domains (2) summary
    COG5034
    Location:7 → 241
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159528183..159536762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237349.5 → XP_006237411.1  inhibitor of growth protein 4 isoform X1

    UniProtKB/TrEMBL
    A6ILQ5
    Related
    ENSRNOP00000024116.8, ENSRNOT00000024116.8
    Conserved Domains (2) summary
    COG5034
    Location:7 → 245
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

  2. XM_006237350.5 → XP_006237412.1  inhibitor of growth protein 4 isoform X2

    UniProtKB/TrEMBL
    A6ILQ5
    Conserved Domains (2) summary
    COG5034
    Location:7 → 244
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

  3. XM_039107453.2 → XP_038963381.1  inhibitor of growth protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8J8YN55, A6ILQ5
    Conserved Domains (2) summary
    COG5034
    Location:7 → 242
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

RNA

  1. XR_005503203.2 RNA Sequence

  2. XR_005503204.2 RNA Sequence

  3. XR_005503205.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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