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P3h3 prolyl 3-hydroxylase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297595, updated on 10-Oct-2024

Summary

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Official Symbol
P3h3provided by RGD
Official Full Name
prolyl 3-hydroxylase 3provided by RGD
Primary source
RGD:1305699
See related
EnsemblRapid:ENSRNOG00000071218 AllianceGenome:RGD:1305699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Leprel2
Summary
Predicted to enable procollagen-proline 3-dioxygenase activity. Predicted to be involved in collagen biosynthetic process; negative regulation of cell population proliferation; and peptidyl-lysine hydroxylation. Predicted to be part of catalytic complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P3H3 (prolyl 3-hydroxylase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 108.4), Lung (RPKM 98.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See P3h3 in Genome Data Viewer
Location:
4q42
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159332514..159348428, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157646242..157662035, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157359331..157375186, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 5 Neighboring gene cell division cycle associated 3 Neighboring gene G protein subunit beta 3 Neighboring gene uncharacterized LOC120102385 Neighboring gene G protein-coupled receptor 162 Neighboring gene Cd4 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA. Hudson DM, et al. J Biol Chem, 2017 Mar 3. PMID 28115524, Free PMC Article
  2. The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. Shah R, et al. Br J Cancer, 2009 May 19. PMID 19436308, Free PMC Article
  3. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. Heard ME, et al. PLoS Genet, 2016 Apr. PMID 27119146, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189333

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine hydroxylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolyl 3-hydroxylase 3
Names
leprecan-like 2
NP_001100090.3
XP_038963377.1
XP_038963378.1
XP_063141978.1
XP_063141979.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106620.3 → NP_001100090.3  prolyl 3-hydroxylase 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0AA76ENW5
    Related
    ENSRNOP00000098013.1, ENSRNOT00000120322.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159332514..159348428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107449.2 → XP_038963377.1  prolyl 3-hydroxylase 3 isoform X1

    Related
    ENSRNOP00000100497.1, ENSRNOT00000135675.1
    Conserved Domains (1) summary
    cl21496
    Location:471 → 633
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  2. XM_063285908.1 → XP_063141978.1  prolyl 3-hydroxylase 3 isoform X2

  3. XM_063285909.1 → XP_063141979.1  prolyl 3-hydroxylase 3 isoform X3

  4. XM_039107450.2 → XP_038963378.1  prolyl 3-hydroxylase 3 isoform X4

RNA

  1. XR_353597.5 RNA Sequence

  2. XR_005503202.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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