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GTF3C1 general transcription factor IIIC subunit 1 [ Homo sapiens (human) ]

Gene ID: 2975, updated on 7-Apr-2024

Summary

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Official Symbol
GTF3C1provided by HGNC
Official Full Name
general transcription factor IIIC subunit 1provided by HGNC
Primary source
HGNC:HGNC:4664
See related
Ensembl:ENSG00000077235 MIM:603246; AllianceGenome:HGNC:4664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC; TFIIIC220; TFIIICalpha
Summary
Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16p12.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (27460613..27549913, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (27739371..27828673, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561234, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 21 receptor Neighboring gene uncharacterized LOC124903668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27460829-27461706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10632 Neighboring gene IL21R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27482643-27483144 Neighboring gene MPRA-validated peak2546 silencer Neighboring gene Sharpr-MPRA regulatory regions 5680 and 15498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10634 Neighboring gene katanin interacting protein Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:27644974-27645660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27648141-27648641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27652441-27653082 Neighboring gene uncharacterized LOC107984874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27711973-27712473 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:27713579-27714080 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:27714081-27714580 Neighboring gene uncharacterized LOC100128079

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells. Vezzoli M, et al. Int J Mol Sci, 2023 Feb 11. PMID 36835038, Free PMC Article
  2. Human transcription factor IIIC box B binding subunit. L'Etoile ND, et al. Proc Natl Acad Sci U S A, 1994 Mar 1. PMID 8127861, Free PMC Article
  3. Purification and characterization of two forms of human transcription factor IIIC. Kovelman R, et al. J Biol Chem, 1992 Dec 5. PMID 1447193
  4. Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories. Crepaldi L, et al. PLoS Genet, 2013. PMID 23966877, Free PMC Article
  5. The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells. Meissner W, et al. J Biol Chem, 2002 Mar 1. PMID 11741993

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18.
    Title: The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18.
  2. The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
    Title: The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
  3. TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.
    Title: TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.
  4. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription
    Title: Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.
  5. Maf1, a repressor that binds and inhibits pol III, is phosphorylated in a mTOR-dependent manner both in vitro and in vivo at serine 75, a site that contributes to its function as a transcriptional inhibitor.
    Title: mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.
  6. Results identify TFIIIC as a recruitment factor for p300 and thus may have important implications for the emerging concept that tRNA genes or TFIIIC binding sites act as chromatin barriers to prohibit spreading of silenced heterochromatin domains.
    Title: Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.
  7. TFIIIC is composed of six subunits, five of which are conserved in humans. We report the identification, molecular cloning, and characterization of the sixth subunit of human TFIIIC, TFIIIC35
    Title: Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.
  8. The partial purification of pol III transcription factors from PE and EC cells revealed that TFIIIC2 activity could be purified from both cell types, whereas TFIIIC1 activity was dramatically reduced in extracts from PE cells.
    Title: The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686A111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
 PubMed 
enables RNA polymerase III general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5S class rRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in rRNA transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in transcription initiation at RNA polymerase III promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
general transcription factor 3C polypeptide 1
Names
TF3C-alpha
TFIIIC 220 kDa subunit
TFIIIC box B-binding subunit
general transcription factor IIIC, polypeptide 1 (alpha subunit)
general transcription factor IIIC, polypeptide 1, alpha 220kDa
transcription factor IIIC 220 kDa subunit
transcription factor IIIC subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286242.2 → NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC002303, AC025275, BC044857, BC137229
    Consensus CDS
    CCDS66988.1
    UniProtKB/TrEMBL
    Q6AHZ7
    Related
    ENSP00000455417.1, ENST00000561623.5
    Conserved Domains (1) summary
    pfam04182
    Location:174 → 250
    B-block_TFIIIC; B-block binding subunit of TFIIIC

  2. NM_001520.4 → NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

    See identical proteins and their annotated locations for NP_001511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC044857, BC137229, BP283960, CA414192
    Consensus CDS
    CCDS32414.1
    UniProtKB/Swiss-Prot
    B2RP21, Q12789, Q12838, Q6DKN9, Q9Y4W9
    UniProtKB/TrEMBL
    Q6AHZ7
    Related
    ENSP00000348510.4, ENST00000356183.9
    Conserved Domains (2) summary
    pfam04182
    Location:174 → 250
    B-block_TFIIIC; B-block binding subunit of TFIIIC
    cl22974
    Location:1881 → 1975
    HpaP; Type III secretion protein (HpaP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    27460613..27549913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434036.1 → XP_047289992.1  general transcription factor 3C polypeptide 1 isoform X2

  2. XM_017023188.3 → XP_016878677.1  general transcription factor 3C polypeptide 1 isoform X1

    UniProtKB/TrEMBL
    Q6AHZ7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    27739371..27828673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380183.1 → XP_054236158.1  general transcription factor 3C polypeptide 1 isoform X2

  2. XM_054380182.1 → XP_054236157.1  general transcription factor 3C polypeptide 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12789.4 GenPept UniProtKB/Swiss-Prot:Q12789

Gene LinkOut

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