Ppp3r2 protein phosphatase 3, regulatory subunit B, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp3r2provided by RGD
Official Full Name: protein phosphatase 3, regulatory subunit B, betaprovided by RGD
Primary source: RGD:69232
See related: AllianceGenome:RGD:69232
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cblp
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and phosphatase binding activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of calcineurin complex. Biomarker of traumatic brain injury. Orthologous to human PPP3R2 (protein phosphatase 3 regulatory subunit B, beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 724.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (68822387..68823382, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (64026903..64027898, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (64945583..64946578, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, CsA normalized the blunted beta-AR responsiveness associated with hypertension.
Title: Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
These data suggest that BK(Ca) channel activity is inhibited by calcineurin, an effect mediated by the association of the calcineurin B subunit with the carboxyl terminus of the channel.
Title: Inhibition of BK channel activity by association with calcineurin in rat brain.
calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation
Title: Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within penetration of zona pellucida	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm mitochondrial sheath	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcineurin subunit B type 2

Names: calcineurin B, type II; calcineurin B-like protein; protein phosphatase 2B regulatory subunit 2

NP_067733.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021701.2 → NP_067733.1 calcineurin subunit B type 2

See identical proteins and their annotated locations for NP_067733.1

Status: PROVISIONAL

Source sequence(s)

D10393

UniProtKB/Swiss-Prot

P28470, Q63878

UniProtKB/TrEMBL

A6KJD5

Conserved Domains (1) summary

COG5126
Location:13 → 157

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]