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Gkn2 gastrokine 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297419, updated on 2-Nov-2024

Summary

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Official Symbol
Gkn2provided by RGD
Official Full Name
gastrokine 2provided by RGD
Primary source
RGD:1311934
See related
EnsemblRapid:ENSRNOG00000009256 AllianceGenome:RGD:1311934
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311934
Summary
Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within response to bacterium. Predicted to be located in basal part of cell. Predicted to be active in extracellular space. Orthologous to human GKN2 (gastrokine 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 3.1), Brain (RPKM 1.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gkn2 in Genome Data Viewer
Location:
4q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121335642..121381680)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119778326..119824366)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119131255..119177329)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329 Neighboring gene gastrokine 1 Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Otto WR, et al. Proteomics, 2006 Aug. PMID 16888721
  2. Gastrokine-2 is transiently expressed in the endodermal and endothelial cells of the maturing mouse yolk sac. Antas VI, et al. Gene Expr Patterns, 2014 Nov. PMID 25290738
  3. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basal part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gastrokine-2
Names
blottin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039686.2 → NP_001034775.1  gastrokine-2 precursor

    See identical proteins and their annotated locations for NP_001034775.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q29TV8
    UniProtKB/TrEMBL
    A6IB04
    Related
    ENSRNOP00000063736.1, ENSRNOT00000067651.4
    Conserved Domains (1) summary
    smart01039
    Location:54 → 149
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    121335642..121381680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107366.1 → XP_038963294.1  gastrokine-2 isoform X2

    UniProtKB/Swiss-Prot
    Q29TV8
    UniProtKB/TrEMBL
    A6IB04
    Conserved Domains (1) summary
    smart01039
    Location:54 → 149
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

  2. XM_039107365.2 → XP_038963293.1  gastrokine-2 isoform X1

    Conserved Domains (1) summary
    smart01039
    Location:63 → 158
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29TV8.1 GenPept UniProtKB/Swiss-Prot:Q29TV8

Gene LinkOut

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