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Nagk N-acetylglucosamine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 297393, updated on 2-Nov-2024

Summary

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Official Symbol
Nagkprovided by RGD
Official Full Name
N-acetylglucosamine kinaseprovided by RGD
Primary source
RGD:1305057
See related
EnsemblRapid:ENSRNOG00000013911 AllianceGenome:RGD:1305057
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylglucosamine kinase activity; N-acylmannosamine kinase activity; and muramyl dipeptide kinase activity. Predicted to be involved in several processes, including N-acetylglucosamine catabolic process; UDP-N-acetylglucosamine biosynthetic process; and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Predicted to act upstream of or within N-acetylglucosamine metabolic process. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 61.7), Adrenal (RPKM 58.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nagk in Genome Data Viewer
Location:
4q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117838761..117846304)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116281179..116293870)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115473848..115485027)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486595 Neighboring gene testis expressed 261 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene uncharacterized LOC134486808

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of Developing Neurons. Islam MA, et al. Mol Cells, 2015 Oct. PMID 26467288, Free PMC Article
  2. The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites. Lee H, et al. Mol Cells, 2014 Mar. PMID 24625575, Free PMC Article
  3. Purification and characterization of N-acetylglucosamine kinase from rat liver--comparison with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Hinderlich S, et al. Eur J Biochem, 1998 Feb 15. PMID 9523722
  4. N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points. Islam MA, et al. Exp Mol Med, 2015 Aug 14. PMID 26272270, Free PMC Article
  5. N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles. Sharif SR, et al. Mol Cells, 2015 May. PMID 25921606, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this work studied the role played by NAGK in axonal development.
    Title: N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of Developing Neurons.
  2. Data shows associations between NAGK, speckle, paraspeckle and general transcription factor suggesting its regulatory roles in gene expression.
    Title: N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles.
  3. The interaction between NAGK and Dynlrb1 frequently occurs at dendritic branch points.
    Title: N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points.
  4. Upregulation of dendritic complexity is a non-canonical function of NAGK.
    Title: The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites.
  5. analysis of oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods
    Title: Evidence for dynamic interplay of different oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124788

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylglucosamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylglucosamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetylglucosamine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables N-acylmannosamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables muramyl dipeptide kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables muramyl dipeptide kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to muramyl dipeptide ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-acetyl-D-glucosamine kinase
Names
N-acetyl-D-mannosamine kinase
glcNAc kinase
muramyl dipeptide kinase
NP_001032857.1
XP_006236802.1
XP_038963273.1
XP_038963274.1
XP_038963275.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037768.1 → NP_001032857.1  N-acetyl-D-glucosamine kinase

    See identical proteins and their annotated locations for NP_001032857.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107647
    UniProtKB/Swiss-Prot
    P81799, Q32Q91
    UniProtKB/TrEMBL
    A0A8L2ULG6, A6IAP9
    Related
    ENSRNOP00000084218.1, ENSRNOT00000108444.2
    Conserved Domains (1) summary
    cl17037
    Location:1 → 279
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117838761..117846304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236740.5 → XP_006236802.1  N-acetyl-D-glucosamine kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJS1
    Related
    ENSRNOP00000093402.1, ENSRNOT00000118649.2
    Conserved Domains (1) summary
    cl17037
    Location:1 → 177
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_039107346.2 → XP_038963274.1  N-acetyl-D-glucosamine kinase isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:1 → 155
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_039107347.2 → XP_038963275.1  N-acetyl-D-glucosamine kinase isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:1 → 157
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_039107345.2 → XP_038963273.1  N-acetyl-D-glucosamine kinase isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:29 → 193
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81799.4 GenPept UniProtKB/Swiss-Prot:P81799

Gene LinkOut

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