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Dguok deoxyguanosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 297389, updated on 10-Oct-2024

Summary

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Official Symbol
Dguokprovided by RGD
Official Full Name
deoxyguanosine kinaseprovided by RGD
Primary source
RGD:1304799
See related
EnsemblRapid:ENSRNOG00000011617 AllianceGenome:RGD:1304799
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable deoxyadenosine kinase activity and deoxyguanosine kinase activity. Involved in ATP biosynthetic process; mitochondrial ATP synthesis coupled electron transport; and negative regulation of neuron projection development. Predicted to be active in cytosol and mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; mitochondrial metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 144.6), Adrenal (RPKM 117.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dguok in Genome Data Viewer
Location:
4q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117544784..117572414, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115987101..116014733, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115180433..115208061, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene bolA family member 3 Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene uncharacterized LOC102548361 Neighboring gene uncharacterized LOC134486594 Neighboring gene uncharacterized LOC120102320 Neighboring gene actin gamma 2, smooth muscle Neighboring gene Stam binding protein Neighboring gene uncharacterized LOC120102321

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats. Vanden Avond MA, et al. J Inherit Metab Dis, 2021 Mar. PMID 33368311
  2. A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome. Jing R, et al. Cell Rep, 2018 Nov 6. PMID 30404003, Free PMC Article
  3. Severe mtDNA depletion and dependency on catabolic lipid metabolism in DGUOK knockout mice. Zhou X, et al. Hum Mol Genet, 2019 Sep 1. PMID 31127938
  4. Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. Bennett B, et al. Free Radic Biol Med, 2016 Mar. PMID 26773591, Free PMC Article
  5. The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. Mandel H, et al. Nat Genet, 2001 Nov. PMID 11687800

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.
    Title: The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.
  2. The goals of this work are to characterize the DGUOK rat in terms of mitochondrial dysfunction and pathological outcome, and to evaluate EPR as a new and additional technique in an integrated characterization of mitochondrial disease .
    Title: Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC188845

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables deoxyguanosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyguanosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deoxynucleoside kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dAMP salvage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dGTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within deoxyribonucleoside monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial ATP synthesis coupled electron transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in purine deoxyribonucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
deoxyguanosine kinase, mitochondrial
NP_001100072.1
XP_006236797.1
XP_006236798.1
XP_006236799.1
XP_008761278.1
XP_008761279.1
XP_038963265.1
XP_038963266.1
XP_038963268.1
XP_038963269.1
XP_063141870.1
XP_063141871.1
XP_063141872.1
XP_063141873.1
XP_063141874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106602.1 → NP_001100072.1  deoxyguanosine kinase, mitochondrial

    See identical proteins and their annotated locations for NP_001100072.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A6IAM4, A6IAM6, D3ZDE4
    Conserved Domains (1) summary
    pfam01712
    Location:41 → 269
    dNK; Deoxynucleoside kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117544784..117572414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107337.2 → XP_038963265.1  deoxyguanosine kinase, mitochondrial isoform X2

    Related
    ENSRNOP00000062535.2, ENSRNOT00000066678.4
    Conserved Domains (1) summary
    pfam01712
    Location:41 → 325
    dNK; Deoxynucleoside kinase

  2. XM_006236737.5 → XP_006236799.1  deoxyguanosine kinase, mitochondrial isoform X6

    See identical proteins and their annotated locations for XP_006236799.1

    UniProtKB/TrEMBL
    A6IAM5, A6IAM6
    Conserved Domains (1) summary
    pfam01712
    Location:41 → 275
    dNK; Deoxynucleoside kinase

  3. XM_008763057.4 → XP_008761279.1  deoxyguanosine kinase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZV32
    Related
    ENSRNOP00000105366.1, ENSRNOT00000135424.1
    Conserved Domains (1) summary
    pfam01712
    Location:41 → 270
    dNK; Deoxynucleoside kinase

  4. XM_063285800.1 → XP_063141870.1  deoxyguanosine kinase, mitochondrial isoform X7

  5. XM_006236735.5 → XP_006236797.1  deoxyguanosine kinase, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A0G2K478
    Related
    ENSRNOP00000072937.2, ENSRNOT00000084388.3
    Conserved Domains (1) summary
    pfam01712
    Location:41 → 331
    dNK; Deoxynucleoside kinase

  6. XM_008763056.4 → XP_008761278.1  deoxyguanosine kinase, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam01712
    Location:41 → 326
    dNK; Deoxynucleoside kinase

  7. XM_039107340.2 → XP_038963268.1  deoxyguanosine kinase, mitochondrial isoform X14

    UniProtKB/TrEMBL
    B5DEP0
    Conserved Domains (1) summary
    cl17190
    Location:1 → 178
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  8. XM_063285802.1 → XP_063141872.1  deoxyguanosine kinase, mitochondrial isoform X10

  9. XM_063285804.1 → XP_063141874.1  deoxyguanosine kinase, mitochondrial isoform X13

  10. XM_063285801.1 → XP_063141871.1  deoxyguanosine kinase, mitochondrial isoform X9

  11. XM_063285803.1 → XP_063141873.1  deoxyguanosine kinase, mitochondrial isoform X11

  12. XM_006236736.5 → XP_006236798.1  deoxyguanosine kinase, mitochondrial isoform X5

    UniProtKB/TrEMBL
    A6IAM6
    Conserved Domains (1) summary
    cl17190
    Location:41 → 293
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  13. XM_039107341.2 → XP_038963269.1  deoxyguanosine kinase, mitochondrial isoform X12

    UniProtKB/TrEMBL
    A6IAM9
    Conserved Domains (1) summary
    cl17190
    Location:41 → 148
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  14. XM_039107338.2 → XP_038963266.1  deoxyguanosine kinase, mitochondrial isoform X8

    Conserved Domains (1) summary
    cl17190
    Location:41 → 147
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein Strain
Heading Accession and Version

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