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Pde1b phosphodiesterase 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 29691, updated on 2-Nov-2024

Summary

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Official Symbol
Pde1bprovided by RGD
Official Full Name
phosphodiesterase 1Bprovided by RGD
Primary source
RGD:3278
See related
EnsemblRapid:ENSRNOG00000036828 AllianceGenome:RGD:3278
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aop2; Pde1b1
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling; cellular response to cytokine stimulus; and monocyte differentiation. Predicted to act upstream of with a positive effect on dopamine catabolic process. Predicted to act upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Located in neuronal cell body. Biomarker of Parkinsonism. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 178.6), Kidney (RPKM 27.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pde1b in Genome Data Viewer
Location:
7q36
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136505834..136533034)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134627378..134654581)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (145117951..145147711)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547836 Neighboring gene gametocyte specific factor 2 Neighboring gene NCK associated protein 1 like Neighboring gene uncharacterized LOC134479586 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1A Neighboring gene glycosylation dependent cell adhesion molecule 1 Neighboring gene uncharacterized LOC102547969

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia. Hayes J, et al. Neuropharmacology, 2021 Mar 15. PMID 33444639
  2. Down-regulation of nitrergic transmission in the rat striatum after chronic nigrostriatal deafferentation. Sancesario G, et al. Eur J Neurosci, 2004 Aug. PMID 15305867
  3. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme. Siuciak JA, et al. Neuropharmacology, 2007 Jul. PMID 17559891
  4. Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. Reed TM, et al. J Neurosci, 2002 Jun 15. PMID 12077213, Free PMC Article
  5. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. Santone R, et al. J Neurosci Res, 2006 Oct. PMID 16881052

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
    Title: Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cyclic-nucleotide phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect dopamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to amphetamine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within serotonin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Names
63 kDa Cam-PDE
anti-oxidant protein 2
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
cam-PDE 1B
cyclic nucleotide phosphodiesterase (CaM-PDE)
phosphodiesterase 1B, Ca2+calmodulin dependent
phosphodiesterase 1B, calmodulin-dependent
phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa
phosphodiesterase IB calmodulin-dependent
NP_073201.1
XP_006242448.1
XP_063119199.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022710.1 → NP_073201.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

    See identical proteins and their annotated locations for NP_073201.1

    Status: PROVISIONAL

    Source sequence(s)
    M94537
    UniProtKB/Swiss-Prot
    Q01066, Q548L3
    UniProtKB/TrEMBL
    A6KD12
    Related
    ENSRNOP00000052147.1, ENSRNOT00000055272.5
    Conserved Domains (2) summary
    pfam00233
    Location:221 → 448
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:80 → 136
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    136505834..136533034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263129.1 → XP_063119199.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2

    UniProtKB/TrEMBL
    A6KD13
    Related
    ENSRNOP00000101163.1, ENSRNOT00000143728.1

  2. XM_006242386.5 → XP_006242448.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8I6ANV0
    Related
    ENSRNOP00000095772.1, ENSRNOT00000099138.2
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 429
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01066.1 GenPept UniProtKB/Swiss-Prot:Q01066

Gene LinkOut

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