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Hepacam2 HEPACAM family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296846, updated on 28-Oct-2024

Summary

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Official Symbol
Hepacam2provided by RGD
Official Full Name
HEPACAM family member 2provided by RGD
Primary source
RGD:1305697
See related
EnsemblRapid:ENSRNOG00000009711 AllianceGenome:RGD:1305697
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305697
Summary
Predicted to be involved in centrosome cycle. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be active in Golgi apparatus; microtubule cytoskeleton; and midbody. Orthologous to human HEPACAM2 (HEPACAM family member 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 53.6), Spleen (RPKM 20.1) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hepacam2 in Genome Data Viewer
Location:
4q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (32400523..32435936, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (31446195..31480859, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (28402862..28437722, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 9 like 2 Neighboring gene sterile alpha motif domain containing 9 like Neighboring gene VPS50 subunit of EARP/GARPII complex Neighboring gene calcitonin receptor Neighboring gene microRNA 653

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. Ozaki Y, et al. Mol Cell, 2012 Sep 14. PMID 22864114
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HEPACAM family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106580.2 → NP_001100050.1  HEPACAM family member 2 precursor

    See identical proteins and their annotated locations for NP_001100050.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168741
    UniProtKB/TrEMBL
    A0A8I5ZP99, B5DEN8
    Related
    ENSRNOP00000080232.2, ENSRNOT00000112288.2
    Conserved Domains (3) summary
    pfam13927
    Location:149 → 224
    Ig_3; Immunoglobulin domain
    cd00096
    Location:167 → 171
    Ig; Ig strand B [structural motif]
    cl11960
    Location:254 → 333
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    32400523..32435936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285722.1 → XP_063141792.1  HEPACAM family member 2 isoform X2

    UniProtKB/TrEMBL
    F7FEX6

  2. XM_063285723.1 → XP_063141793.1  HEPACAM family member 2 isoform X3

    UniProtKB/TrEMBL
    F7FEX6

  3. XM_039107255.2 → XP_038963183.1  HEPACAM family member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP99, B5DEN8
    Conserved Domains (3) summary
    pfam13927
    Location:149 → 224
    Ig_3; Immunoglobulin domain
    cd00096
    Location:167 → 171
    Ig; Ig strand B [structural motif]
    cl11960
    Location:254 → 333
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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