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Rint1 RAD50 interactor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296750, updated on 2-Nov-2024

Summary

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Official Symbol
Rint1provided by RGD
Official Full Name
RAD50 interactor 1provided by RGD
Primary source
RGD:1560433
See related
EnsemblRapid:ENSRNOG00000022182 AllianceGenome:RGD:1560433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560433
Summary
Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; regulation of ER to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 71.6), Adrenal (RPKM 66.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rint1 in Genome Data Viewer
Location:
4q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (12211806..12248117, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (11319416..11355740, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7851602..7885446, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909675 Neighboring gene small nucleolar RNA, C/D box 93 Neighboring gene translocase of outer mitochondrial membrane 7 Neighboring gene pseudouridine synthase 7 Neighboring gene small nucleolar RNA SNORD93

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. Xiao J, et al. J Biol Chem, 2001 Mar 2. PMID 11096100
  2. RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. Arasaki K, et al. Mol Biol Cell, 2006 Jun. PMID 16571679, Free PMC Article
  3. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
  4. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. Hirose H, et al. EMBO J, 2004 Mar 24. PMID 15029241, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Dsl1/NZR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Dsl1/NZR complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAD50-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399263.1 → NP_001386192.1  RAD50-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5ZVY6, A6K582
    Related
    ENSRNOP00000082957.1, ENSRNOT00000106589.2
    Conserved Domains (1) summary
    pfam04437
    Location:304 → 784
    RINT1_TIP1; RINT-1 / TIP-1 family

  2. NM_001399264.1 → NP_001386193.1  RAD50-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Conserved Domains (1) summary
    pfam04437
    Location:125 → 605
    RINT1_TIP1; RINT-1 / TIP-1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    12211806..12248117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285696.1 → XP_063141766.1  RAD50-interacting protein 1 isoform X1

  2. XM_039108555.2 → XP_038964483.1  RAD50-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    pfam04437
    Location:1 → 476
    RINT1_TIP1; RINT-1 / TIP-1 family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials