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Fut7 fucosyltransferase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296564, updated on 28-Oct-2024

Summary

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Official Symbol
Fut7provided by RGD
Official Full Name
fucosyltransferase 7provided by RGD
Primary source
RGD:735019
See related
EnsemblRapid:ENSRNOG00000014156 AllianceGenome:RGD:735019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fuc-TVII; FucT-VII
Summary
Enables alpha-(1->3)-fucosyltransferase activity. Involved in inflammatory response. Predicted to be located in trans-Golgi network. Orthologous to human FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Spleen (RPKM 10.6), Thymus (RPKM 8.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fut7 in Genome Data Viewer
Location:
3p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28635913..28640407)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8237687..8242273)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2637281..2646497)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene neural proliferation, differentiation and control, 1 Neighboring gene ribosomal protein L28, pseudogene 4 Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene chloride intracellular channel 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and expression of rat fucosyltransferase VII at sites of inflammation. Niittymäki J, et al. APMIS, 2005 Sep. PMID 16218937
  2. Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene. Bengtson P, et al. J Biol Chem, 2001 Aug 24. PMID 11404359
  3. Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. Natsuka S, et al. J Biol Chem, 1994 Jun 17. PMID 8207002
  4. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. Knibbs RN, et al. J Cell Biol, 1996 May. PMID 8666674, Free PMC Article
  5. Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII. Stroud MR, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299472

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-(1->3)-fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in embryo implantation ISO
Inferred from Sequence Orthology
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leukocyte migration involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte migration involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte migration involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lymphocyte migration into lymph node ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphocyte migration into lymph node ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lymphocyte migration into lymphoid organs ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte tethering or rolling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neutrophil migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of type IV hypersensitivity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-(1,3)-fucosyltransferase 7
Names
alpha (1,3) fucosyltransferase
fucosyltransferase VII
galactoside 3-L-fucosyltransferase
selectin ligand synthase
NP_955785.1
XP_006233647.1
XP_006233648.1
XP_006233649.1
XP_038960642.1
XP_038960643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431519.1 → NP_001418448.1  alpha-(1,3)-fucosyltransferase 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001431520.1 → NP_001418449.1  alpha-(1,3)-fucosyltransferase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001431521.1 → NP_001418450.1  alpha-(1,3)-fucosyltransferase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_199491.3 → NP_955785.1  alpha-(1,3)-fucosyltransferase 7 isoform 2

    See identical proteins and their annotated locations for NP_955785.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q712G6
    Related
    ENSRNOP00000033858.4, ENSRNOT00000037169.6
    Conserved Domains (2) summary
    pfam00852
    Location:197 → 365
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:72 → 182
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28635913..28640407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233587.5 → XP_006233649.1  alpha-(1,3)-fucosyltransferase 7 isoform X5

    Conserved Domains (2) summary
    pfam00852
    Location:145 → 313
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:20 → 130
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. XM_006233585.5 → XP_006233647.1  alpha-(1,3)-fucosyltransferase 7 isoform X1

    Related
    ENSRNOP00000105710.1, ENSRNOT00000169795.1
    Conserved Domains (2) summary
    pfam00852
    Location:207 → 375
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 192
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. XM_006233586.5 → XP_006233648.1  alpha-(1,3)-fucosyltransferase 7 isoform X2

    Conserved Domains (2) summary
    pfam00852
    Location:180 → 348
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:55 → 165
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  4. XM_039104715.2 → XP_038960643.1  alpha-(1,3)-fucosyltransferase 7 isoform X4

    Related
    ENSRNOP00000100129.1, ENSRNOT00000173038.1
    Conserved Domains (2) summary
    pfam00852
    Location:168 → 336
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:43 → 153
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  5. XM_039104714.2 → XP_038960642.1  alpha-(1,3)-fucosyltransferase 7 isoform X3

    UniProtKB/TrEMBL
    A6JT59
    Related
    ENSRNOP00000100712.1, ENSRNOT00000123679.1
    Conserved Domains (2) summary
    pfam00852
    Location:169 → 337
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:44 → 154
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q712G6.1 GenPept UniProtKB/Swiss-Prot:Q712G6

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