U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dtwd1 DTW domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296119, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dtwd1provided by RGD
Official Full Name
DTW domain containing 1provided by RGD
Primary source
RGD:1311144
See related
EnsemblRapid:ENSRNOG00000009593 AllianceGenome:RGD:1311144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311144
Summary
Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be active in nucleus. Orthologous to human DTWD1 (DTW domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 23.0), Testes (RPKM 22.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dtwd1 in Genome Data Viewer
Location:
3q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133845768..133859965)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113392402..113409322)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118427790..118443003)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene ATPase phospholipid transporting 8B4 (putative) Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biogenesis and functions of aminocarboxypropyluridine in tRNA. Takakura M, et al. Nat Commun, 2019 Dec 5. PMID 31804502, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA-uridine aminocarboxypropyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-uridine aminocarboxypropyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-uridine aminocarboxypropyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-uridine aminocarboxypropyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tRNA-uridine aminocarboxypropyltransferase 1
Names
DTW domain-containing protein 1
NP_001013943.2
NP_001380702.1
XP_006234976.1
XP_017447067.1
XP_038960493.1
XP_063139395.1
XP_063139396.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013921.2 → NP_001013943.2  tRNA-uridine aminocarboxypropyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6AYF5

  2. NM_001393773.1 → NP_001380702.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6AYF5

  3. NM_001430097.1 → NP_001417026.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HPY2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    133845768..133859965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234914.5 → XP_006234976.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:81 → 304
    DTW; DTW domain

  2. XM_063283325.1 → XP_063139395.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

    Related
    ENSRNOP00000099621.1, ENSRNOT00000124932.1

  3. XM_063283326.1 → XP_063139396.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X4

  4. XM_039104565.2 → XP_038960493.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6AYF5
    UniProtKB/TrEMBL
    A6HPY2
    Related
    ENSRNOP00000012966.4, ENSRNOT00000012966.5
    Conserved Domains (1) summary
    pfam03942
    Location:81 → 304
    DTW; DTW domain

  5. XM_017591578.3 → XP_017447067.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZV5, F1M7Q4
    Related
    ENSRNOP00000085303.1, ENSRNOT00000120319.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYF5.1 GenPept UniProtKB/Swiss-Prot:Q6AYF5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools