Clnk cytokine-dependent hematopoietic cell linker [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clnkprovided by RGD
Official Full Name: cytokine-dependent hematopoietic cell linkerprovided by RGD
Primary source: RGD:1562417
See related: EnsemblRapid:ENSRNOG00000051169 AllianceGenome:RGD:1562417
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mist; RGD1562417
Summary: Predicted to be involved in several processes, including mast cell degranulation; negative regulation of natural killer cell activation; and positive regulation of natural killer cell cytokine production. Predicted to be located in mast cell granule. Predicted to be part of protein-containing complex. Orthologous to human CLNK (cytokine dependent hematopoietic cell linker). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 25.5), Lung (RPKM 14.6) and 8 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (76136446..76315364)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (71923894..72101180)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (76657165..76834050)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell cytokine production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mast cell granule	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

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The following sections contain reference sequences that belong to a specific genome build. Explain