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Dennd2c DENN domain containing 2C [ Rattus norvegicus (Norway rat) ]

Gene ID: 295333, updated on 2-Nov-2024

Summary

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Official Symbol
Dennd2cprovided by RGD
Official Full Name
DENN domain containing 2Cprovided by RGD
Primary source
RGD:1308197
See related
EnsemblRapid:ENSRNOG00000018716 AllianceGenome:RGD:1308197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308197
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in nucleoplasm. Orthologous to human DENND2C (DENN domain containing 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 60.0), Muscle (RPKM 50.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dennd2c in Genome Data Viewer
Location:
2q34
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (193310822..193378986)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (190622357..190690489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (205592348..205660619)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NRAS proto-oncogene, GTPase Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene BCAS2, pre-mRNA processing factor Neighboring gene carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 2C
Names
DENN/MADD domain containing 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191569.1 → NP_001178498.1  DENN domain-containing protein 2C

    See identical proteins and their annotated locations for NP_001178498.1

    Status: VALIDATED

    Source sequence(s)
    BM385166, JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2JTT3, D3ZX30
    Related
    ENSRNOP00000025365.5, ENSRNOT00000025365.7
    Conserved Domains (3) summary
    smart00801
    Location:810 → 876
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:482 → 571
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:581 → 765
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    193310822..193378986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233071.5 → XP_006233133.1  DENN domain-containing protein 2C isoform X1

    See identical proteins and their annotated locations for XP_006233133.1

    UniProtKB/TrEMBL
    A0A0G2JTT3, D3ZX30
    Conserved Domains (3) summary
    smart00801
    Location:810 → 876
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:482 → 571
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:581 → 765
    DENN; DENN (AEX-3) domain

  2. XM_006233069.3 → XP_006233131.1  DENN domain-containing protein 2C isoform X1

    See identical proteins and their annotated locations for XP_006233131.1

    UniProtKB/TrEMBL
    A0A0G2JTT3, D3ZX30
    Conserved Domains (3) summary
    smart00801
    Location:810 → 876
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:482 → 571
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:581 → 765
    DENN; DENN (AEX-3) domain

  3. XM_039102070.2 → XP_038957998.1  DENN domain-containing protein 2C isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTT3, D3ZX30
    Conserved Domains (3) summary
    smart00801
    Location:810 → 876
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:482 → 571
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:581 → 765
    DENN; DENN (AEX-3) domain

  4. XM_039102069.2 → XP_038957997.1  DENN domain-containing protein 2C isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTT3, D3ZX30
    Conserved Domains (3) summary
    smart00801
    Location:810 → 876
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:482 → 571
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:581 → 765
    DENN; DENN (AEX-3) domain

  5. XM_063281634.1 → XP_063137704.1  DENN domain-containing protein 2C isoform X2

  6. XM_006233070.5 → XP_006233132.1  DENN domain-containing protein 2C isoform X1

    See identical proteins and their annotated locations for XP_006233132.1

    UniProtKB/TrEMBL
    A0A0G2JTT3, D3ZX30
    Conserved Domains (3) summary
    smart00801
    Location:810 → 876
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:482 → 571
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:581 → 765
    DENN; DENN (AEX-3) domain
Nucleotide Protein Strain
Heading Accession and Version

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