Tmod4 tropomodulin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmod4provided by RGD
Official Full Name: tropomodulin 4provided by RGD
Primary source: RGD:1308940
See related: EnsemblRapid:ENSRNOG00000021088 AllianceGenome:RGD:1308940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to be active in striated muscle thin filament. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward (RPKM 2345.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185384547..185389549)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182695709..182700540)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (196294990..196299896)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tropomodulin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106449.2 → NP_001099919.1 tropomodulin-4

See identical proteins and their annotated locations for NP_001099919.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

FM111895, FN800735, JAXUCZ010000002

UniProtKB/TrEMBL

A6K2U7, D3ZSG3

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001270650.1 → NP_001257579.1 tropomodulin-4

See identical proteins and their annotated locations for NP_001257579.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.

Source sequence(s)

FM111895, FN800735, JAXUCZ010000002

UniProtKB/TrEMBL

A6K2U7, D3ZSG3

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001270651.1 → NP_001257580.1 tropomodulin-4

See identical proteins and their annotated locations for NP_001257580.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

FM111895, FN800735, JAXUCZ010000002

UniProtKB/TrEMBL

A6K2U7, D3ZSG3

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001270652.1 → NP_001257581.1 tropomodulin-4

See identical proteins and their annotated locations for NP_001257581.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

FM111895, FN800735, JAXUCZ010000002

UniProtKB/TrEMBL

A6K2U7, D3ZSG3

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001270653.1 → NP_001257582.1 tropomodulin-4

See identical proteins and their annotated locations for NP_001257582.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

FM111895, FN800735, JAXUCZ010000002

UniProtKB/TrEMBL

A6K2U7, D3ZSG3

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

185384547..185389549

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281624.1 → XP_063137694.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281621.1 → XP_063137691.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281619.1 → XP_063137689.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281618.1 → XP_063137688.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281622.1 → XP_063137692.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281625.1 → XP_063137695.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281623.1 → XP_063137693.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_063281620.1 → XP_063137690.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3
XM_039102047.2 → XP_038957975.1 tropomodulin-4 isoform X1

UniProtKB/TrEMBL

A6K2U7, D3ZSG3

Related

ENSRNOP00000074417.1, ENSRNOT00000088312.3

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...