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UL27 envelope glycoprotein B [ Suid alphaherpesvirus 1 ]

Gene ID: 2952558, updated on 18-Aug-2023

Summary

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Gene symbol
UL27
Gene description
envelope glycoprotein B
Locus tag
SuHV1_gp14
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_006151.1 (16808..19722, complement)

NC_006151.1Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein N Neighboring gene tegument protein VP22 Neighboring gene transactivating tegument protein VP16 Neighboring gene tegument protein VP13/14 Neighboring gene tegument protein VP11/12 Neighboring gene DNA packaging terminase subunit 2 Neighboring gene single-stranded DNA-binding protein Neighboring gene DNA polymerase catalytic subunit Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006151.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops. Vallbracht M, et al. J Virol, 2018 Jan 1. PMID 29046441, Free PMC Article
  2. Virion-incorporated glycoprotein B mediates transneuronal spread of pseudorabies virus. Curanovic D, et al. J Virol, 2009 Aug. PMID 19494011, Free PMC Article
  3. Proteolytic cleavage of glycoprotein B is dispensable for in vitro replication, but required for syncytium formation of pseudorabies virus. Okazaki K. J Gen Virol, 2007 Jul. PMID 17554016
  4. Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner. Chen M, et al. J Virol, 2022 Oct 26. PMID 36173190, Free PMC Article
  5. Complete, annotated sequence of the pseudorabies virus genome. Klupp BG, et al. J Virol, 2004 Jan. PMID 14671123, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
    Title: Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
  2. Data found that PrV gB FL residues Trp187, Tyr192, Phe275, and Tyr276, were essential for liposome binding and for fusion in cellular and viral contexts, form a continuous hydrophobic patch at the gB trimer surface. These results allow to propose a molecular model to understand how the initial interactions by gBs from all herpesviruses with target membranes are established.
    Title: Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.
  3. gB is not required for the sorting of virions into infected neurons or the release of virions from the axon.
    Title: Virion-incorporated glycoprotein B mediates transneuronal spread of pseudorabies virus.
  4. gB cleavage is involved in syncytium formation but not in penetration kinetics, suggesting that different mechanisms operate between cell-cell fusion and virus-cell fusion by PRV.
    Title: Proteolytic cleavage of glycoprotein B is dispensable for in vitro replication, but required for syncytium formation of pseudorabies virus.
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General gene information

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Homology

regulatory

  • Loc: c16835-16830 experiment = consistent with mRNA size and sense in strain Ka (UL27) , inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence
  • Loc: c19722-19716 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box

General protein information

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Preferred Names
envelope glycoprotein B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006151.1 Reference assembly

    Range
    16808..19722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_068330.1 envelope glycoprotein B [Suid alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_068330.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08355
    UniProtKB/TrEMBL
    G3G951, Q5PPC7
    Conserved Domains (1) summary
    PHA03231
    Location:87 → 911
    PHA03231; glycoprotein BALF4; Provisional
Nucleotide Protein
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