Slc22a6 solute carrier family 22 member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a6provided by RGD
Official Full Name: solute carrier family 22 member 6provided by RGD
Primary source: RGD:69338
See related: EnsemblRapid:ENSRNOG00000018215 AllianceGenome:RGD:69338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oat1; Paht; Roat1; Orctl1
Summary: Enables several functions, including chloride ion binding activity; prostaglandin transmembrane transporter activity; and secondary active transmembrane transporter activity. Involved in several processes, including metanephric proximal tubule development; prostaglandin transport; and sodium-independent organic anion transport. Acts upstream of or within organic anion transport. Located in caveola. Part of protein-containing complex. Orthologous to human SLC22A6 (solute carrier family 22 member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1961.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (214951493..214960317)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205522579..205531179)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (224824809..224833284)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.
Title: Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.
Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
Title: Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice.
Title: Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice.
Study results indicate that Oat1 and Oat3 at the blood-arachnoid barrier provide a distinct clearance pathway of organic anion drugs from cerebrospinal fluid independently of choroid plexus.
Title: Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of Rats.
These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4
Title: Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.
Furosemide pretreatment causes a decrease of p-aminohippurate renal elimination in rats in spite of the increased expression level of Oat1.
Title: Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions.
folic acid was capable of preventing monosodium urate-induced OAT1 relocation by inhibiting the RhoA signaling pathway.
Title: Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy.
In uremia, urea accounts, at least in part, for the decreased expression of Oat1 and Oat3 in proximal tubule plasma membranes.
Title: Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels.
Suggest that 1,25(OH)2 D3 treatment reduces cefdinir and cefadroxil clearances by diminution of renal OAT1/OAT3 expression.
Title: Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.
Data show that lycopene upregulated the organic anion transporters (OAT1 and OAT3) and organic cation transporters (OCT1 and OCT2) in cisplatin-induced acute renal injury.
Title: Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc22a6 (e-PCR), detects polymorphism
- UniSTS:463373

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-ketoglutarate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables chloride ion binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-independent organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	ISO Inferred from Sequence Orthology more info
involved_in alpha-ketoglutarate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inorganic anion transport	IEA Inferred from Electronic Annotation more info
involved_in metanephric proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal tubular secretion	ISO Inferred from Sequence Orthology more info
involved_in renal tubular secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium-independent organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium-independent organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 22 member 6

Names: organic anion transporter 1; organic cationic transporter-like 1; rROAT1; renal organic anion transporter 1; solute carrier family 22 (organic anion transporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017224.2 → NP_058920.1 solute carrier family 22 member 6

See identical proteins and their annotated locations for NP_058920.1

Status: PROVISIONAL

Source sequence(s)

BC104692

UniProtKB/Swiss-Prot

O35956

UniProtKB/TrEMBL

A6HZR6

Related

ENSRNOP00000024756.2, ENSRNOT00000024757.6

Conserved Domains (2) summary

cd06174
Location:135 → 505

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 515

2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

214951493..214960317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230978.4 → XP_006231040.1 solute carrier family 22 member 6 isoform X1

Conserved Domains (2) summary

cd06174
Location:135 → 456

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 471

2A0119; cation transport protein