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Cox7a2 cytochrome c oxidase subunit 7A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29507, updated on 2-Nov-2024

Summary

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Official Symbol
Cox7a2provided by RGD
Official Full Name
cytochrome c oxidase subunit 7A2provided by RGD
Primary source
RGD:68365
See related
EnsemblRapid:ENSRNOG00000042903 AllianceGenome:RGD:68365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox7a3
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex. Orthologous to several human genes including COX7A2 (cytochrome c oxidase subunit 7A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 6460.7), Muscle (RPKM 4016.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cox7a2 in Genome Data Viewer
Location:
8q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (89597051..89611032, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (80716824..80720922, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (87209529..87213627, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene Sec61 translocon subunit gamma like 1 Neighboring gene transmembrane protein 30A Neighboring gene filamin A interacting protein 1 Neighboring gene uncharacterized LOC134480210 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of cDNA encoding subunit VIIa of rat liver cytochrome c oxidase. Enders C, et al. Nucleic Acids Res, 1990 Dec 11. PMID 2175887, Free PMC Article
  2. Isoforms of mammalian cytochrome c oxidase: correlation with human cytochrome c oxidase deficiency. Kennaway NG, et al. Pediatr Res, 1990 Nov. PMID 2175025
  3. Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform. Schägger H, et al. Eur J Biochem, 1995 May 15. PMID 7601105
  4. Structure of the intact 14-subunit human cytochrome c oxidase. Zong S, et al. Cell Res, 2018 Oct. PMID 30030519, Free PMC Article
  5. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of respiratory chain complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 7A2, mitochondrial
Names
cytochrome c oxidase polypeptide 7A2, mitochondrial
cytochrome c oxidase polypeptide VIIa-liver/heart
cytochrome c oxidase subunit VIIa 3
cytochrome c oxidase subunit VIIa polypeptide 2
cytochrome c oxidase subunit VIIa-L
cytochrome c oxidase subunit VIIa-liver/heart
cytochrome c oxidase, subunit 7a 3
cytochrome c oxidase, subunit VIIa 2
NP_071948.1
XP_063121086.1
XP_063121087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022503.2 → NP_071948.1  cytochrome c oxidase subunit 7A2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_071948.1

    Status: VALIDATED

    Source sequence(s)
    AW521400, BG668415
    UniProtKB/Swiss-Prot
    P35171
    UniProtKB/TrEMBL
    A0A8L2QTB7, B2RYS0
    Related
    ENSRNOP00000098381.1, ENSRNOT00000120756.2
    Conserved Domains (1) summary
    cd00928
    Location:24 → 78
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    89597051..89611032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265017.1 → XP_063121087.1  cytochrome c oxidase subunit 7A2, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    P35171
    UniProtKB/TrEMBL
    B2RYS0

  2. XM_063265016.1 → XP_063121086.1  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35171.1 GenPept UniProtKB/Swiss-Prot:P35171

Gene LinkOut

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