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Tm4sf1 transmembrane 4 L six family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295061, updated on 2-Nov-2024

Summary

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Official Symbol
Tm4sf1provided by RGD
Official Full Name
transmembrane 4 L six family member 1provided by RGD
Primary source
RGD:1309652
See related
EnsemblRapid:ENSRNOG00000015812 AllianceGenome:RGD:1309652
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within blastocyst formation. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human TM4SF1 (transmembrane 4 L six family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 138.6), Kidney (RPKM 77.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tm4sf1 in Genome Data Viewer
Location:
2q26
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (143606980..143616176, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (141456950..141466146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147382866..147392062, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 23 Neighboring gene uncharacterized LOC120100824 Neighboring gene uncharacterized LOC134485620 Neighboring gene minichromosome maintenance complex component 4, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension. Hong J, et al. Am J Respir Cell Mol Biol, 2023 Apr. PMID 36252184, Free PMC Article
  2. Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody. Marken JS, et al. J Biol Chem, 1994 Mar 11. PMID 7510285
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.
    Title: Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane 4 L6 family member 1
Names
transmembrane 4 superfamily member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106434.1 → NP_001099904.1  transmembrane 4 L6 family member 1

    See identical proteins and their annotated locations for NP_001099904.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474003
    UniProtKB/TrEMBL
    A6JVF9, D4ACP4
    Related
    ENSRNOP00000021536.5, ENSRNOT00000021535.7
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 194
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    143606980..143616176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281586.1 → XP_063137656.1  transmembrane 4 L6 family member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ30
    Related
    ENSRNOP00000109282.1, ENSRNOT00000132709.1

  2. XM_039102015.2 → XP_038957943.1  transmembrane 4 L6 family member 1 isoform X2

    UniProtKB/TrEMBL
    A6JVG0
    Conserved Domains (1) summary
    pfam05805
    Location:4 → 138
    L6_membrane; L6 membrane protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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