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Alg5 ALG5, dolichyl-phosphate beta-glucosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 295051, updated on 2-Nov-2024

Summary

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Official Symbol
Alg5provided by RGD
Official Full Name
ALG5, dolichyl-phosphate beta-glucosyltransferaseprovided by RGD
Primary source
RGD:1308900
See related
EnsemblRapid:ENSRNOG00000058694 AllianceGenome:RGD:1308900
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dolichyl-phosphate beta-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of or within determination of left/right symmetry. Predicted to be active in cytoplasmic side of rough endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in polycystic kidney disease 7. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 98.2), Liver (RPKM 90.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Alg5 in Genome Data Viewer
Location:
2q26
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141087126..141101397)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (138936998..138951228)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143932242..143946472)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon GGC) Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene exosome component 8 Neighboring gene SMAD family member 9 Neighboring gene uncharacterized LOC120100820 Neighboring gene regulatory factor X-associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichyl-phosphate beta-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dolichyl-phosphate beta-glucosyltransferase
Names
asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog
NP_001020578.1
XP_006232395.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025407.1 → NP_001020578.1  dolichyl-phosphate beta-glucosyltransferase

    See identical proteins and their annotated locations for NP_001020578.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098039
    UniProtKB/TrEMBL
    A0A0G2JTP4, A0A8I6GKU7, A6JVD5, Q4QQS6
    Related
    ENSRNOP00000068790.1, ENSRNOT00000088575.3
    Conserved Domains (1) summary
    cd04188
    Location:69 → 289
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    141087126..141101397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232333.3 → XP_006232395.1  dolichyl-phosphate beta-glucosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006232395.1

    UniProtKB/TrEMBL
    A0A8I6GIJ2, A0A8I6GKU7, A6JVD2
    Related
    ENSRNOP00000090803.1, ENSRNOT00000109521.2
    Conserved Domains (1) summary
    cd04188
    Location:55 → 275
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
Nucleotide Protein Strain
Heading Accession and Version

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