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Slc20a2 solute carrier family 20 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29502, updated on 2-Nov-2024

Summary

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Official Symbol
Slc20a2provided by RGD
Official Full Name
solute carrier family 20 member 2provided by RGD
Primary source
RGD:3699
See related
EnsemblRapid:ENSRNOG00000019490 AllianceGenome:RGD:3699
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ram1; Glvr2; Pit-2; RAM-1; Ab1-188
Summary
Enables sodium:phosphate symporter activity. Predicted to be involved in phosphate ion transmembrane transport and positive regulation of bone mineralization. Located in apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human SLC20A2 (solute carrier family 20 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 231.6), Liver (RPKM 124.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc20a2 in Genome Data Viewer
Location:
16q12.5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76163315..76253881, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69460850..69551418, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74318287..74408030, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene voltage-dependent anion channel 3 like 1 Neighboring gene voltage-dependent anion channel 3 Neighboring gene uncharacterized LOC120097400 Neighboring gene small integral membrane protein 19 Neighboring gene uncharacterized LOC120097532 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene solute carrier family 25 member 15 Neighboring gene lncRNA derived from hepatocytes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Villa-Bellosta R, et al. Am J Physiol Renal Physiol, 2009 Apr. PMID 19073637, Free PMC Article
  2. Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells. Wada K, et al. J Cell Physiol, 2004 Jan. PMID 14584042
  3. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Miller DG, et al. Proc Natl Acad Sci U S A, 1994 Jan 4. PMID 8278411, Free PMC Article
  4. Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Villa-Bellosta R, et al. Pflugers Arch, 2010 Feb. PMID 19841935
  5. Characterization of phosphate transport in rat vascular smooth muscle cells: implications for vascular calcification. Villa-Bellosta R, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17322102

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression in renal brush border reduced by parathyroid hormone
    Title: Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.
  2. Results describe the regulation of the sodium/phosphate cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and acidosis in rat kidney.
    Title: Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
  3. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
    Title: Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
  4. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.
    Title: The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.
  5. We have used RNA interference to demonstrate that Pit1 and Pit2 are the transporters responsible for Na-dependent Pi transport in VSMCs.
    Title: Characterization of phosphate transport in rat vascular smooth muscle cells: implications for vascular calcification.
  6. mRNA expression level of Glvr-2 was increased by the addition of inorganic phosphate (Pi) in bone marrow stromal cells
    Title: Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells.
  7. PiT-1 (Slc20a1) and PiT-2 (Slc20a2) were detected at the basolateral membrane of hepatocytes.
    Title: Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transporter 2
Names
gibbon ape leukemia virus receptor 2
phosphate transporter 2
receptor for amphitropic viruses 1
receptor for amphotropic viruses 1
solute carrier family 20 (phosphate transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017223.2 → NP_058919.1  sodium-dependent phosphate transporter 2

    See identical proteins and their annotated locations for NP_058919.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070908
    UniProtKB/Swiss-Prot
    Q63488
    Related
    ENSRNOP00000026418.7, ENSRNOT00000026418.9
    Conserved Domains (1) summary
    pfam01384
    Location:478 → 638
    PHO4; Phosphate transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    76163315..76253881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094428.2 → XP_038950356.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q63488
    Conserved Domains (1) summary
    pfam01384
    Location:478 → 638
    PHO4; Phosphate transporter family

  2. XM_008771352.4 → XP_008769574.1  sodium-dependent phosphate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_008769574.1

    UniProtKB/Swiss-Prot
    Q63488
    Conserved Domains (1) summary
    pfam01384
    Location:478 → 638
    PHO4; Phosphate transporter family

  3. XM_008771351.4 → XP_008769573.1  sodium-dependent phosphate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_008769573.1

    UniProtKB/Swiss-Prot
    Q63488
    Conserved Domains (1) summary
    pfam01384
    Location:478 → 638
    PHO4; Phosphate transporter family

  4. XM_017600054.3 → XP_017455543.1  sodium-dependent phosphate transporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q63488
    Conserved Domains (1) summary
    pfam01384
    Location:478 → 638
    PHO4; Phosphate transporter family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63488.1 GenPept UniProtKB/Swiss-Prot:Q63488

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