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Sec62 SEC62 homolog, preprotein translocation factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 294912, updated on 17-Aug-2024

Summary

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Official Symbol
Sec62provided by RGD
Official Full Name
SEC62 homolog, preprotein translocation factorprovided by RGD
Primary source
RGD:1308862
See related
AllianceGenome:RGD:1308862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tloc1; Ab2-292
Summary
Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to act upstream of or within posttranslational protein targeting to endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 438.8), Brain (RPKM 390.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sec62 in Genome Data Viewer
Location:
2q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114499317..114526705, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112570810..112598198, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (116188736..116225510, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene polyhomeotic homolog 3 Neighboring gene uncharacterized LOC120100793 Neighboring gene G protein-coupled receptor 160 Neighboring gene uncharacterized LOC134485610 Neighboring gene uncharacterized LOC120100794 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene glutathione peroxidase 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. Haßdenteufel S, et al. Cell Rep, 2018 May 1. PMID 29719251, Free PMC Article
  2. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
translocation protein SEC62
Names
translocation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393776.1 → NP_001380705.1  translocation protein SEC62

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6IHL0, A6IHL1
    Conserved Domains (2) summary
    pfam03839
    Location:87 → 306
    Sec62; Translocation protein Sec62
    NF033609
    Location:291 → 375
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    114499317..114526705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034129.1: Suppressed sequence

    Description
    NM_001034129.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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